Authors: Kotfis K, Lechowicz K, Drozdzal S, Wojdacz TK, Grywalska E PMID: 33477294 PMCID: PMC7830835 DOI: 10.3390/ph14010071 Abstract In March 2020, coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was declared a global pandemic by the World Health Organization (WHO). The clinical course of the disease is unpredictable but may lead to severe acute respiratory infection [...]

Authors: Choudhury IM, Shabnam N, Ahsan T, Kabir S, Ahsan SM. DOI: https://doi.org/10.3329/brc.v7i1.54245 Abstract Background: The sudden onset of COVID-19 began in late 2019 caused by a novel coronavirus (SARS-COV2) and on 11th March, WHO declared it to have developed pandemic status. There is still no specific treatment and vaccine available for COVID-19; causing wide [...]

Authors: McCullough PA, Alexander PE, Armstrong R, Arvinte C, Bain AF, Bartlett RP et al. PMID: 33387997 DOI: 10.31083/j.rcm.2020.04.264 Abstract The SARS-CoV-2 virus spreading across the world has led to surges of COVID-19 illness, hospitalizations, and death. The complex and multifaceted pathophysiology of life-threatening COVID-19 illness including viral mediated organ damage, cytokine storm, and thrombosis [...]

Authors: Darban M, Malek F, Memarian M, Gohari A, Kiani A, Emadi A doi: https://doi.org/10.22037/jcma.v6i2.32182 Abstract INTRODUCTION: Our aim was to investigate the efficacy of vitamin C, melatonin, and zinc in patients with severe Covid-19. METHODS: Twenty-one adult patients were randomized 1:1 to standard care alone or standard care plus IV vitamin C (2 g, [...]

Authors:Seneviratne CJ, Balan P, Ki KK, Udawatte NS, Lai D. PMID: PMC7734110 DOI: 10.1007/s15010-020-01563-9 Abstract Purpose: One of the key approaches to minimize the risk of COVID-19 transmission would be to reduce the titres of SARS-CoV-2 in the saliva of infected COVID-19 patients. This is particularly important in high-risk procedures like dental treatment. The present [...]

Authors: Lenze EJ, Mattar C, Zorumski CF, Stevens A, Nicol GE, Miller JP PMID: 33180097 PMCID: PMC7662481 DOI: 10.1001/jama.2020.22760 Abstract Importance: Coronavirus disease 2019 (COVID-19) may lead to serious illness as a result of an excessive immune response. Fluvoxamine may prevent clinical deterioration by stimulating the σ-1 receptor, which regulates cytokine production. Objective: To determine [...]

Authors: Kalfas S, Visvanathan K, Chan K, Drago J doi: https://doi.org/10.1101/2020.11.30.20236570 Abstract Introduction Ivermectin is a commonly used antihelminthic agent with over 35 years of established safety data in humans. Recent data demonstrates antiviral activity in vitro against SARS-CoV-2, in addition to a range of viruses. In vitro and animal models also provide evidence of [...]

Authors:Gandolfi JV, Di Bernardo AP, Chanes DA, Martin DF, Joles VB, Amendola CP et al. PMID:33048904 DOI: 10.1097/CCM.0000000000004690 Abstract Objectives: To evaluate whether the use of exogenous melatonin affects sleep, reduces the prevalence of delirium, and decreases the need for analgosedation and to assess whether serum melatonin indices correlate with exogenous administration in critically ill [...]

Authors: Agrawal PK, Agrawal C, Blunden G. doi: https://doi.org/10.1177/1934578X20976293 Abstract Quercetin, a naturally occurring dietary flavonoid, is well known to ameliorate chronic diseases and aging processes in humans, and its antiviral properties have been investigated in numerous studies. In silico and in vitro studies demonstrated that quercetin can interfere with various stages of the coronavirus [...]

Authors: Jo S, Kim S, Shin DH, Kim MS. PMID: 31724441 PMCID: PMC6882434 DOI: 10.1080/14756366.2019.1690480 Abstract There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against [...]