Authors: Hamed MG, Hagaga RS PMID: 32768893 PMCID: PMC7382922 DOI: 10.1016/j.mehy.2020.110140 Abstract While researchers are struggling to develop a vaccine for coronavirus disease, it is important to evolve effective therapeutic strategies to save lives. The majority of coronavirus disease deaths are due to pneumonia. Mostly, stress and depression are associated with coronavirus disease infection and [...]

Authors: McCoy J, Goren A, Cadegiani FA, Vano-Galvan S, Kovacevic M, Situm M et al. PMID: 34350193 PMCID: PMC8326462 DOI: 10.3389/fmed.2021.668698 Abstract Antiandrogens have demonstrated a protective effect for COVOD-19 patients in observational and interventional studies. The goal of this study was to determine if proxalutamide, an androgen receptor antagonist, could [...]

Authors: Cadegiani FA, Goren A, Wambier CG, McCoy J PMID: 34249367 PMCID: PMC8262389 DOI: 10.1016/j.nmni.2021.100915 Abstract In a prospective observational study (pre-AndroCoV Trial), the use of nitazoxanide, ivermectin and hydroxychloroquine demonstrated unexpected improvements in COVID-19 outcomes when compared to untreated patients. The apparent yet likely positive results raised ethical concerns on the employment of further [...]

Authors: Hill A, Garratt A, Levi J, Falconer J, Ellis L, McCann K et al. PMID: 34796244 PMCID: PMC8420640 DOI: 10.1093/ofid/ofab358 Abstract Ivermectin is an antiparasitic drug being investigated for repurposing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ivermectin showed in vitro activity against SARS-COV-2, but only at high concentrations. This meta-analysis investigated ivermectin [...]

Authors: Assimakopoulos SF, Aretha D, Kominos D, Dimitropoulou D, Lagadinou M PMID: 34182881 DOI: 10.1080/23744235.2021.1945675 Abstract Background: N-acetyl-cysteine (NAC) has been previously shown to exert beneficial effects in diverse respiratory diseases, through antioxidant and anti-inflammatory actions. Our aim was to evaluate NAC potential impact in hospitalised patients with COVID-19 pneumonia, in [...]

Authors: Altay O, Arif M, Li X, Yang H, Aydin M, Alkurt G PMID: 34180141 PMCID: PMC8420376 DOI: 10.1002/advs.202101222 Abstract COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD+ ) and glutathione metabolism. Here it is investigated if administration of a mixture of combined metabolic activators (CMAs) [...]

Authors:Farnoosh G, Akbaariqomix M, Badri T, Bagheri M, Izadi M. PMID: PMC8220995 DOI: 10.1016/j.arcmed.2021.06.006 Abstract Background: Melatonin has been known as an anti-inflammatory agent and immune modulator that may address progressive pathophysiology of coronavirus disease 2019 (COVID-19). Aim of the study: To evaluate the clinical efficacy of adjuvant, use of melatonin [...]

Authors: Cadegiani FA, McCoy J, Zimerman A, Mirza FN, Barros RN doi: https://doi.org/10.1101/2021.06.22.21259318 Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectivity is mediated by the androgen-promoted protease, transmembrane protease, serine 2 (TMPRSS2). Previously, we have shown that treatment with proxalutamide, a non-steroidal androgen receptor antagonist, accelerates viral clearance and [...]

Authors: Bryant A, Lawrie TA, Dowswell T, Fordham E, Mitchell S, Hill SR et al. PMID: 34145166 PMCID: PMC8248252 DOI: 10.1097/MJT.0000000000001402 Abstract Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty: We assessed the [...]

Authors: Ahmadi R, Salari S, Reihani H, Eslami S. PMID: PMC8358331 DOI: 10.1002/fsn3.2226 Abstract Background: Curcumin, a natural polyphenolic compound, is proposed as a potential treatment option for patients with coronavirus disease by inhibiting the entry of virus to the cell, encapsulation of the virus and viral protease, as well as modulating various cellular signaling [...]