Auhtors: Bower JE, Partridge AH, Wolff AC, Thorner ED, Irwin MR, Joffe H, et al. PMID: 34406839 PMCID: PMC8547916 DOI: 10.1200/JCO.21.00279 Abstract Purpose: Younger women are at risk for depression and related symptoms following breast cancer. The Pathways to Wellness study, a randomized, multi-institution, three-arm trial, tested the efficacy of two behavioral interventions for younger [...]

Auhtors: Carlberg C, Velleuer E PMID: 34411566 DOI: 10.1016/j.bcp.2021.114735 Abstract Uncontrolled overgrowth of cells, such as in cancer, is an unavoidable risk in life that affects nearly every second individual in industrialized countries. However, in part this risk can be controlled through lifestyle adjustments, such as the avoidance of smoking, unhealthy diet, obesity, physical inactivity [...]

Auhtors: Wang Y, Lu X, Wang X, Qiu Q, Zhu P, Ma L, et al. PMID: 34384247 PMCID: PMC8484060 DOI: 10.1161/CIRCRESAHA.121.319104 Abstract Rationale: Anthracycline-induced cardiotoxicity (AIC) is a major side effect that limits the use of anthracyclines as effective chemotherapeutics. No mechanism-based therapy is available when cardiac function deteriorates. Objective: We aim to elucidate the [...]

Auhtors: Nishikawa H, Goto M, Fukunishi S, Asai A, Nishiguchi S, Higuchi K PMID: 34445197 PMCID: PMC8395185 DOI: 10.3390/ijms22168491 Abstract The term "cachexia" is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer, chronic heart failure, chronic renal failure, and autoimmune diseases, and [...]

Auhtors: Rascio F, Spadaccino F, Rocchetti MT, Castellano G, Stallone G, Netti GS, Ranieri E PMID: 34439105 PMCID: PMC8394096 DOI: 10.3390/cancers13163949 Abstract The PI3K/AKT pathway is one of the most frequently over-activated intracellular pathways in several human cancers. This pathway, acting on different downstream target proteins, contributes to the carcinogenesis, proliferation, invasion, and metastasis of [...]

Auhtors: Gorabi AM, Kiaie N, Aslani S, Sathyapalan T, Jamialahmadi T, Sahebkar A PMID: 34373771 PMCID: PMC8349293 DOI: 10.1155/2021/9599608 Abstract Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attributed to statins, including neuroprotection, antioxidation, anti-inflammation, and [...]

Auhtors: Khandelwal A, Singh GP, Jamil S PMID: 34334890 PMCID: PMC8313054 DOI: 10.1016/j.mjafi.2021.06.002 No abstract available Keywords: Anti-viral; COVID-19; Ivermectin; SARS-CoV-2 Source: https://pubmed.ncbi.nlm.nih.gov/34334890/ Archive: https://archive.is/uArVB

Auhtors: Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M PMID: 34298810 PMCID: PMC8304632 DOI: 10.3390/cancers13143597 Abstract The tumor microenvironment includes dendritic cells, T-cytotoxic, T-helper, reactive B-lymphoid cells and macrophages; these reactive cells could interplay with malignant cells and promote tumor growth and survival. Among its cellular components, tumor-associated macrophages (TAM) represent a component [...]

Auhtors: Lee KA, Luong MK, Shaw H, Nathan P, Bataille V, Spector TD Abstract The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug [...]

Auhtors: Wastyk HC, Fragiadakis GK, Perelman D, Dahan D, Merrill BD, Yu FB, et al. PMID: 34256014 PMCID: PMC9020749 DOI: 10.1016/j.cell.2021.06.019 Abstract Diet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence the human microbiome and immune system [...]