Auhtors: Medini H, Zirmman A, Mishmar D PMID: 34812416 PMCID: PMC8599136 DOI: 10.1016/j.isci.2021.103471 Abstract Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections. Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available bulk RNA-seq datasets from COVID-19 patients and corresponding healthy controls (three blood datasets, N = [...]

Auhtors: Ferraresi A, Esposito A, Girone C, Vallino L, Salwa A, Ghezzi I, et al. PMID: 34831435 PMCID: PMC8625920 DOI: 10.3390/cells10113213 Abstract Background: Ovarian cancer progression and invasiveness are promoted by a range of soluble factors released by cancer cells and stromal cells within the tumor microenvironment. Our previous studies demonstrated that resveratrol (RV), a [...]

Auhtors: Zhao Z, Zeng J, Guo Q, Pu K, Yang Y, Chen N, et al. PMID: 34869024 PMCID: PMC8634032 DOI: 10.3389/fonc.2021.775418 Abstract Background: Cancer stem cells (CSCs) are able to survive after cancer therapies, resulting in tumor progression and recurrence, as is seen in colorectal cancer. Therapies targeting CSCs are regarded as novel and promising [...]

Auhtors: Pasvol TJ, Macgregor EA, Rait G, Horsfall L PMID: 34782337 PMCID: PMC9279840 DOI: 10.1136/bmjsrh-2021-201260 Abstract Background: Over the last 20 years, new contraceptive methods became available and incentives to increase contraceptive uptake were introduced. We aimed to describe temporal trends in non-barrier contraceptive prescribing in UK primary care for the period 2000-2018. Methods: A [...]

Auhtors: Browne AJ, Chipeta MG, Haines-Woodhouse G, Kumaran EPA, Hamadani BHK, Zaraa S, et al. PMID: 34774223 PMCID: PMC8654683 DOI: 10.1016/S2542-5196(21)00280-1 Abstract Background: Antimicrobial resistance (AMR) is a serious threat to global public health. WHO emphasises the need for countries to monitor antibiotic consumption to combat AMR. Many low-income and middle-income countries (LMICs) lack surveillance [...]

Auhtors: Büttner-Teleagă A, Kim YT, Osel T, Richter K PMID: 34770209 PMCID: PMC8583058 DOI: 10.3390/ijerph182111696 Abstract Introduction: Sleep disorders, especially insomnia, are very common in different kinds of cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is caused by different reasons and usually appears as a comorbid disorder to different [...]

Auhtors: Zhang J-J, Wang D-W, Cai D, Lu Q, Cheng Y-X PMID: 34805099 PMCID: PMC8595597 DOI: 10.3389/fchem.2021.772740 Abstract Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganoderma lucidum. Their structures [...]

Auhtors: Veglia F, Sanseviero E, Gabrilovich DI PMID: 34620838 PMCID: PMC8497485 DOI: 10.1038/s41392-021-00670-9 Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities. Besides, this [...]

Auhtors: Azadi R, Mousavi SE, Kazemi NM, Yousefi-Manesh H, Rezayat SM, Jaafari MR PMID: 34600570 PMCID: PMC8487542 DOI: 10.1186/s40360-021-00525-7 Abstract Background: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on [...]

Auhtors: Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, Chaves L PMID: 34599743 PMCID: PMC8487226 DOI: 10.1007/s11481-021-10015-6 Abstract Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-inflammation and neuronal damage result in a [...]