Auhtors: Li L, Connelly MC, Wetmore C, Curran T, Morgan JI PMID: 12782575 Abstract Cancer cells escape from growth control by accumulating genetic and epigenetic alterations. In rare instances, epigenetic changes alone are oncogenic. Furthermore, agents that modify DNA methylation or chromatin structure can restore a normal phenotype to cells harboring oncogenic mutations. However, it [...]

Auhtors: Li C, Allen A, Kwagh J, Doliba NM, Qin W, Najafi H, et al. PMID: 16476731 DOI: 10.1074/jbc.M512792200 Abstract Insulin secretion by pancreatic beta-cells is stimulated by glucose, amino acids, and other metabolic fuels. Glutamate dehydrogenase (GDH) has been shown to play a regulatory role in this process. The importance of GDH was underscored [...]

Auhtors: Guezva JM, Krajewska M, de Heredia ML, Krajewski S, Santamaria G, Kim H, et al. PMID: 12438266 Abstract Mitochondrial H+-ATP synthase is required for cellular energy provision and for efficient execution of apoptosis. Almost one century ago, Otto Warburg proposed the hypothesis that mitochondrial function might be impaired in cancer cells. However, his hypothesis [...]

Auhtors: Delsite R, Kachhap S, Anbazhagan R, Gabrielson E, Singh KK PMID: 12495447 PMCID: PMC149409 DOI: 10.1186/1476-4598-1-6 Abstract Background: The interaction of nuclear and mitochondrial genes is an essential feature in maintenance of normal cellular function. Of 82 structural subunits that make up the oxidative phosphorylation system in the mitochondria, mitochondrial DNA (mtDNA) encodes 13 [...]

Auhtors: Nowell PC PMID: 12147207 DOI: 10.1016/s1044-579x(02)00012-3 Abstract It has long been known that tumors become more clinically and biologically aggressive over time. This has been termed 'tumor progression' and includes, among other properties invasion and metastasis, as well as more efficient escape from host immune regulation. Since 1960, first cytogenetics and then molecular techniques [...]

Auhtors: Klimp AH, Hollema H, Kempinga C, van der Zee AG, de Vries EG, Daemen T PMID: 11585770 Abstract This study investigates whether and to what extent cyclooxygenase type-2 (COX-2) and inducible nitric oxide-synthase (iNOS), both known to have an immunosuppressive effect, are expressed in human ovarian tumors. Because COX-2 and iNOS can be expressed [...]

Auhtors: John AP PMID: 11601863 DOI: 10.1054/mehy.2001.1335 Abstract It has been known for decades that cancer cells produce excessive amounts of lactic acid. The fact that most cancers have poor vascular systems has led cancer scientists to assume that such cells are deprived of a normal supply of oxygen. Researchers believe that without sufficient oxygen, [...]

Auhtors: Ayre SG, Bellon DP, Garcia DP, Jr. PMID: 11000062 DOI: 10.1054/mehy.2000.1063 Abstract The endogenous molecular biology of cancer cells involves autocrine and paracrine secretion of insulin and insulin-like growth-factors I and II, which subserve energy production and growth stimulation, respectively, in these cells. These activities confer on cancer its malignant potential, working as they [...]

Auhtors: McCarty OJ, Mousa SA, Bray PF, Konstantopoulos K PMID: 10961878 Abstract Accumulating evidence suggests that successful metastatic spread may depend on the ability of tumor cells to undergo extensive interactions with platelets. However, the mechanisms mediating tumor cell adhesion to platelets under conditions of flow remain largely unknown. Therefore, this study was designed to [...]

Auhtors: Westerdahl J, Ingvar C, Mâsbäck A, Olsson H PMID: 10861466 DOI: 10.1002/1097-0215(20000701)87:13.0.co;2-3 Abstract In a new population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma, between 1995 and 1997, and 913 healthy controls aged 16 to 80 years, the association between sunscreen use and malignant [...]