Auhtors: Chen Y, Cairns R, Papandreou I, Koong A, Denko NC PMID: 19753307 PMCID: PMC2737639 DOI: 10.1371/journal.pone.0007033 Abstract Background: The unique metabolism of tumors was described many years ago by Otto Warburg, who identified tumor cells with increased glycolysis and decreased mitochondrial activity. However, "aerobic glycolysis" generates fewer ATP per glucose molecule than mitochondrial oxidative [...]

Auhtors: Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, et al. PMID: 19698742 DOI: 10.1016/j.mam.2009.08.002 Abstract Mitochondria are required for cellular survival, yet can also orchestrate cell death. The peculiar biochemical properties of these organelles, which are intimately linked to their compartmentalized ultrastructure, provide an optimal microenvironment for multiple biosynthetic and [...]

Auhtors: Watson J Abstract THE National Cancer Institute, which has overseen American efforts on researching and combating cancers since 1971, should take on an ambitious new goal for the next decade: the development of new drugs that will provide lifelong cures for many, if not all, major cancers. Beating cancer now is a realistic ambition [...]

Auhtors: Mavropoulos JC, Buschemeyer WC, Tewari AK, Rokheld D, Pollak M, Zhao Y PMID: 19470786 PMCID: PMC3774034 DOI: 10.1158/1940-6207.CAPR-08-0188 Abstract Purpose: Numerous dietary factors elevate serum levels of insulin and insulin-like growth factor I (IGF-I), both potent prostate cancer mitogens. We tested whether varying dietary carbohydrate and fat, without energy restriction relative to comparison diets, [...]

Auhtors: Vander Heiden MG, Cantley LC, Thompson CB PMID: 19460998 PMCID: PMC2849637 DOI: 10.1126/science.1160809 Abstract In contrast to normal differentiated cells, which rely primarily on mitochondrial oxidative phosphorylation to generate the energy needed for cellular processes, most cancer cells instead rely on aerobic glycolysis, a phenomenon termed "the Warburg effect." Aerobic glycolysis is an inefficient [...]

Auhtors: Hobday RA, Cason JW. PMID: 19461112 PMCID: PMC4504358 DOI: 10.2105/AJPH.2008.134627 Abstract The H1N1 "Spanish flu" outbreak of 1918-1919 was the most devastating pandemic on record, killing between 50 million and 100 million people. Should the next influenza pandemic prove equally virulent, there could be more than 300 million deaths globally. The conventional view is [...]

Auhtors: Koike K PMID: 19464104 DOI: 10.1016/j.canlet.2009.04.010 Abstract Hepatitis B virus (HBV) is a small hepatotropic and highly species-specific enveloped DNA virus. The carcinogenicity of this virus has become focused on the X gene and its coded X protein. The X protein itself is unable to bind to DNA directly, but works as a potent [...]

Auhtors: Kapoor S PMID: 19418593 PMCID: PMC2678591 DOI: 10.3748/wjg.15.2170 Abstract Nigella sativa (N. sativa) decreases DNA damage and thereby prevents initiation of carcinogenesis in colonic tissue secondary to exposure to toxic agents such as azoxymethane. N. sativa is of immense therapeutic benefit in diabetic individuals and those with glucose intolerance as it accentuates glucose-induced secretion [...]

Auhtors: Bonorden MJ, Rogozina OP, Kluczny CM, Grossmann ME, Grambsch PL, Grande JP, Perkins S PMID: 19235043 DOI: 10.1080/01635580802419798 Abstract Prostate cancer is the most frequently diagnosed cancer in men. Whereas chronic calorie restriction (CCR) delays prostate tumorigenesis in some rodent models, the impact of intermittent caloric restriction (ICR) has not been determined. Here, transgenic [...]

Auhtors: Mathupala SP, Ko YH, Pedersen PL PMID: 19101634 PMCID: PMC2714668 DOI: 10.1016/j.semcancer.2008.11.006 Abstract The most common metabolic hallmark of malignant tumors, i.e., the "Warburg effect" is their propensity to metabolize glucose to lactic acid at a high rate even in the presence of oxygen. The pivotal player in this frequent cancer phenotype is mitochondrial-bound [...]