Auhtors: Teepen JC, van Dijck JA PMID: 22437882 DOI: 10.1002/ijc.27542 Abstract The increasing exposure to electromagnetic fields (EMFs) has raised concern, as increased exposure may result in an increased risk of childhood leukemia (CL). Besides a short introduction of CL and EMF, our article gives an evaluation of the evidence of a causal relation between [...]

Auhtors: Fridman WH, Pagès F, Sautès-Fridman C, Galon J PMID: 22419253 DOI: 10.1038/nrc3245 Abstract Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this [...]

Auhtors: Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Pistoria V, Wei M. PMID: 22323820 PMCID: PMC3608686 DOI: 10.1126/scitranslmed.3003293 Abstract Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells [...]

Auhtors: Bhardwaj K, Liu P, Leibowitz JL, Kao CC PMID: 22301153 PMCID: PMC3318636 DOI: 10.1128/JVI.07012-11 Abstract Coronaviruses encode an endoribonuclease, Nsp15, which has a poorly defined role in infection. Sequence analysis revealed a retinoblastoma protein-binding motif (LXCXE/D) in the majority of the Nsp15 of the severe acute respiratory syndrome coronavirus (SARS-CoV) and its orthologs in [...]

Auhtors: Corkey BE PMID: 22187369 PMCID: PMC3237642 DOI: 10.2337/db11-1483 Abstract The Banting Medal for Scientific Achievement Award is the American Diabetes Association's highest scientific award and honors an individual who has made significant, long-term contributions to the understanding of diabetes, its treatment, and/or prevention. The award is named after Nobel Prize winner Sir Frederick Banting, [...]

Auhtors: Pesch B, Kendzia B, Gustavsson P, Jöckel KH, Johnen G, Pohlabeln H, et al. PMID: 22052329 PMCID: PMC3296911 DOI: 10.1002/ijc.27339 Abstract Lung cancer is mainly caused by smoking, but the quantitative relations between smoking and histologic subtypes of lung cancer remain inconclusive. By using one of the largest lung cancer datasets ever assembled, we [...]

Auhtors: Labelle M, Begum S, Hynes RO PMID: 22094253 PMCID: PMC3487108 DOI: 10.1016/j.ccr.2011.09.009 Abstract Interactions of cancer cells with the primary tumor microenvironment are important determinants of cancer progression toward metastasis but it is unknown whether additional prometastatic signals are provided during the intravascular transit to the site of metastasis. Here, we show that platelet-tumor [...]

Auhtors: Bin YS, Marshall NS, Glozier N PMID: 22075214 DOI: 10.1016/j.smrv.2011.07.003 Abstract Objectives: Little evidence exists to support the common assertion that adult sleep duration has declined. We investigated secular trends in sleep duration over the past 40 years through a systematic review. Methods: Systematic search of 5 electronic databases was conducted to identify repeat [...]

Auhtors: Li M, Li C, Allen A, Stanley CA, Smith TJ PMID: 22079166 PMCID: PMC3294041 DOI: 10.1016/j.abb.2011.10.015 Abstract Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators [...]

Auhtors: Chen Q, Zhang XH, Massagu J PMID: 22014578 PMCID: PMC3293160 DOI: 10.1016/j.ccr.2011.08.025 Abstract Aberrant expression of vascular cell adhesion molecule-1 (VCAM-1) in breast cancer cells is associated with lung relapse, but the role of VCAM-1 as a mediator of metastasis has remained unknown. We report that VCAM-1 provides a survival advantage to breast cancer [...]