Auhtors: Musella M, Manic G, De Maria R, Vitale I, Sistigu A PMID: 28638743 PMCID: PMC5467995 DOI: 10.1080/2162402X.2017.1314424 Abstract If there is a great new hope in the treatment of cancer, the immune system is it. Innate and adaptive immunity either promote or attenuate tumorigenesis and so can have opposing effects on the therapeutic outcome. [...]

Auhtors: Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, et al. PMID: 28377387 PMCID: PMC5628103 DOI: 10.1136/gutjnl-2016-313413 Abstract Objective: Recent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the [...]

Auhtors: León D, Uribe E, Zambrano A, Salas M PMID: 28272357 PMCID: PMC6155386 DOI: 10.3390/molecules22030398 Abstract Resveratrol-a polyphenol of natural origin-has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use [...]

Auhtors: Shishehbor F, Mansoori A, Shirani F PMID: 28292654 DOI: 10.1016/j.diabres.2017.01.021 Abstract Objective: Postprandial hyperglycemia plays a decisive role in the development of chronic metabolic disorders. The effect of vinegar intake with a meal on postprandial glucose has been studied in several trials with conflicting results. Research methods and procedures: The purpose of the current [...]

Auhtors: Hamer J, Warner E PMID: 28246240 PMCID: PMC5318212 DOI: 10.1503/cmaj.160464 Abstract Although more than 90% of patients with breast cancer have early stage disease at diagnosis, about 25% will eventually die of distant metastasis.1 Many patients with breast cancer seek information from a variety of sources about behaviours that may reduce their risk of [...]

Auhtors: Kniotek M, Boguska A PMID: 28316997 PMCID: PMC5337856 DOI: 10.1155/2017/4541958 Abstract Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5. cGMP is a secondary messenger activating protein kinases and a common [...]

Auhtors: Puchalska P, Crawford PA PMID: 28178565 PMCID: PMC5313038 DOI: 10.1016/j.cmet.2016.12.022 Abstract Ketone body metabolism is a central node in physiological homeostasis. In this review, we discuss how ketones serve discrete fine-tuning metabolic roles that optimize organ and organism performance in varying nutrient states and protect from inflammation and injury in multiple organ systems. Traditionally [...]

Auhtors: Nowell CS, Radtke F PMID: 28154375 DOI: 10.1038/nrc.2016.145 Abstract The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch [...]

Authors: Christofferson T Abstract A masterful synchronization of history and cutting-edge science shines new light on humanity's darkest diagnosis. In the wake of the Cancer Genome Atlas project's failure to provide a legible roadmap to a cure for cancer, science writer Travis Christofferson illuminates a promising blend of old and new perspectives on the disease. [...]

Auhtors: Xing Y, Liqi Z, Jian L, Qinghua Y, Qian Y PMID: 28203548 PMCID: PMC5285722 DOI: 10.3389/fcimb.2017.00021 Abstract Previous reports have demonstrated that the second-generation tetracycline derivative doxycycline (DOX) interrupts mitochondrial proteostasis and physiology, inhibits proliferation of many cell types, and induces apoptosis. However, the effects of DOX, which is widely used in porcine husbandry [...]