Auhtors: Lopez P, Galvao DA, Taaffe DR, Newton RU, Souza G, Trajano GS, Pinto RS PMID: 32815096 DOI: 10.1007/s12282-020-01147-3 Abstract Background: Exercise is recognised as an adjunct therapy for breast cancer patients; however, little is known about the resistance training dose-response. We conducted a systematic review and meta-regression to examine the resistance training dose-response (i.e., [...]

Auhtors: Langade D, Thakare V, Kanchi S, Kelgane S PMID: 32818573 DOI: 10.1016/j.jep.2020.113276 Abstract Ethnopharmacological relevance: Ashwagandha (Withania somnifera (L.) Dunal.) is long known for its sleep-inducing effects. Ashwagandha can be proposed as an alternative to the recommended present treatments for insomnia. This study aimed to evaluate the pharmacological effect of Ashwagandha root extract on [...]

Auhtors: Andersson CR, Selvin T, Blom K, Rubin J, Berglund M, Jarvius M, et al. PMID: 32753665 PMCID: PMC7403428 DOI: 10.1038/s41598-020-68986-0 Abstract We recently showed that the anti-helminthic compound mebendazole (MBZ) has immunomodulating activity in monocyte/macrophage models and induces ERK signalling. In the present study we investigated whether MBZ induced ERK activation is shared by [...]

Auhtors: Heiskanen V, Pfiffner M, Partonen T doi: https://doi.org/10.1016/j.arr.2020.101089 Abstract Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast [...]

Auhtors: Rainey NE, Moustapha A, Petit PX PMID: 32765806 PMCID: PMC7387956 DOI: 10.1155/2020/3656419 Abstract Curcumin has extensive therapeutic potential because of its antioxidant, anti-inflammatory, and antiproliferative properties. Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers. These potent effects are driven by curcumin's ability to induce G2/M [...]

Auhtors: Li C, Jiang P, Wei S, Xu X, Wang J PMID: 32680511 PMCID: PMC7367382 DOI: 10.1186/s12943-020-01234-1 Abstract Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tumours and hampering effective antitumour immune responses in tumour-bearing hosts, constitute [...]

Auhtors: Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, et al. PMID: 20631080 PMCID: PMC4675145 DOI: 10.1158/0008-5472.CAN-10-0706 Abstract The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice [...]

Auhtors: Szurpnicka A, Kowalczuk A, Szterk A PMID: 32621089 PMCID: PMC7340679 DOI: 10.1007/s12272-020-01247-w Abstract Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro [...]

Auhtors: Diorio C, Kelly KM, Afungchwi GM, Ladas EJ, Marjerrison S PMID: 32614139 DOI: 10.1002/pbc.28324 Abstract Traditional and complementary medicine (T&CM) strategies are commonly used by pediatric cancer patients. Nutritional approaches to T&CM include bioactive compounds, supplements, and herbs as well as dietary approaches. Pediatric cancer patients and their families commonly request and use nutritional [...]

Auhtors: AlGhamdi AA, Mohammed MRS, Zamzami MA, Al-Malki AL, Qari MH, Khan MI, Choudhry H PMID: 32560283 PMCID: PMC7353463 DOI: 10.3390/nu12061792 Abstract Thymoquinone (TQ), a naturally occurring anticancer compound extracted from Nigella sativa oil, has been extensively reported to possess potent anti-cancer properties. Experimental studies showed the anti-proliferative, pro-apoptotic, and anti-metastatic effects of TQ on [...]