Auhtors: Matthan NR, Ausman LM, Meng H, Tighiouart H, Lichtenstein AH PMID: 27604773 PMCID: PMC5039811 DOI: 10.3945/ajcn.116.137208 Abstract Background: The utility of glycemic index (GI) values for chronic disease risk management remains controversial. Although absolute GI value determinations for individual foods have been shown to vary significantly in individuals with diabetes, there is a dearth [...]

Auhtors: Itani O, Jike M, Watanabe N, Kaneita Y PMID: 27743803 DOI: 10.1016/j.sleep.2016.08.006 Abstract Objective: The dose-response of short sleep duration in mortality has been studied, in addition to the incidences of notable health complications and diseases such as diabetes mellitus, hypertension, cardiovascular diseases, stroke, coronary heart diseases, obesity, depression, and dyslipidemia. Methods: We collected [...]

Authors: Rahimi HR, Nedaeinia R, Shamloo AS, Nikdoust S. PMID: 27516979 PMCID: PMC4967834 Abstract Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). [...]

Auhtors: Marinac CR, Nelson SH, Breen CI, Hartman SJ, Natarajan L, Pierce JP, et al. PMID: 27032109 PMCID: PMC4982776 DOI: 10.1001/jamaoncol.2016.0164 Abstract Importance: Rodent studies demonstrate that prolonged fasting during the sleep phase positively influences carcinogenesis and metabolic processes that are putatively associated with risk and prognosis of breast cancer. To our knowledge, no studies [...]

Authors: Wang W, Sun C, Mao L, Ma P, Liu F, Yang J. doi: https://doi.org/10.1016/j.tifs.2016.07.004 Abstract Background Quercetin, one of the most well-known flavonoids, has been included in human diet for a long history. The use of quercetin has been widely associated with a great number of health benefits, including antioxidant, anti-inflammatory, antiviral and anticancer [...]

Auhtors: Pedersen HK, Gudmundsdottir V, Nielsen HB, Hyotylainen T, Nielsen T, Jensen BA, et al. PMID: 27409811 DOI: 10.1038/nature18646 Abstract Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish [...]

Auhtors: Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. PMID: 27381735 PMCID: PMC4935811 DOI: 10.1038/ncomms12150 Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both [...]

Authors: Mogil RJ, Kaste SC, Ferry RJ, Hudson MM, Howell CR PMID: 26967465 PMCID: PMC4945422 DOI: 10.1001/jamaoncol.2015.6557 Abstract Importance: Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis. Objective: To evaluate the ability of [...]

Authors: Leyva-Lopez N, Gutierrez-Grijalva EP, Ambriz-Perez D. PMID: PMC4926454 DOI: 10.3390/ijms17060921 Abstract High levels of cytokines, such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6, are associated with chronic diseases like rheumatoid arthritis, asthma, atherosclerosis, Alzheimer's disease and cancer; therefore cytokine inhibition might be an important target for the treatment of these diseases. Most [...]

Auhtors: Liu WM, Scott KA, Dennis JL, Kaminska E, Levett AJ, Dalgleish AG PMID: 27279602 DOI: 10.3892/ijo.2016.3567 Abstract It has been reported that lower doses of the opioid antagonist naltrexone are able to reduce tumour growth by interfering with cell signalling as well as by modifying the immune system. We have evaluated the gene expression [...]