Auhtors: Yuan C, Bao Y, Sato K, Nimptsch K, Song M, Brand-Miller JC, et al. PMID: 28817837 PMCID: PMC5625675 DOI: 10.1038/bjc.2017.272 Abstract Background: Although hyperinsulinemia is hypothesised to be involved in colorectal carcinogenesis, it remains unclear whether a diet inducing an elevated insulin response influences colorectal cancer (CRC) survival. Methods: We examined the association of [...]

Authors: Nieman DC, Ramamoorthy S, Kay CD, Goodman CL, Capps CR, Shue ZL. PMID: 28631923 DOI: 10.1021/acs.jproteome.7b00196 Abstract This study evaluated the effect of ingesting a flavonoid-rich supplement (329 mg/d) on total urine phenolics and shifts in plasma metabolites in overweight/obese female adults using untargeted metabolomics procedures. Participants (N = 103, 18-65 y, BMI ≥ [...]

Authors: Mokhtari RB, Baluch N, Homayouni TS, Kumar S, Yeger H PMID: 28735362 PMCID: PMC5842175 DOI: 10.1007/s12079-017-0401-y Abstract Cancer is a multi-stage process resulting from aberrant signaling pathways driving uncontrolled proliferation of transformed cells. The development and progression of cancer from a premalignant lesion towards a metastatic tumor requires accumulation of mutations in many regulatory [...]

Auhtors: Singh VK, Saini A, Chandra R PMID: 28785557 PMCID: PMC5520001 DOI: 10.3389/fmolb.2017.00052 Abstract Cancer stem cells (CSCs) are believed to exhibit distinctive self-renewal, proliferation, and differentiation capabilities, and thus play a significant role in various aspects of cancer. CSCs have significant impacts on the progression of tumors, drug resistance, recurrence and metastasis in different [...]

Authors: Barabutis N, Khangoora V, Marik PE, Catravas JD PMID: 28739448 PMCID: PMC5812759 DOI: 10.1016/j.chest.2017.07.014 Abstract Background: Sepsis refers to the dysregulated host immune response elicited by microbial infections resulting in life-threatening organ dysfunction. Sepsis represents a medical challenge, since it is associated with a rate of death as high as 60%. Septic shock is [...]

Authors: Cialdella-Kam L, Ghosh S, Meaney MP, Knab AM, Shanely RA, Nieman DC. PMID: 28753942 PMCID: PMC5537887 DOI: 10.3390/nu9070773 Abstract Quercetin (Q) and green tea extract (E) are reported to counter insulin resistance and inflammation and favorably alter fat metabolism. We investigated whether a mixture of E + Q (EQ) could synergistically influence metabolic and [...]

Auhtors: Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, et al. PMID: 28720668 DOI: 10.1158/1078-0432.CCR-16-3102 Abstract Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer; [...]

Authors: Lee CR, Zeldin DC PMID: 26605933 PMCID: PMC5512422 doi: 10.1056/NEJMcibr1511280 Abstract Severe sepsis remains a major public health problem associated with poor clinical outcomes and substantial health care expenditures. Although the number of sepsis cases in the United States exceeds 750,000 per year and sepsis is associated with an estimated mortality rate of 20–30%, [...]

Authors: Kunutsor SK, Seidu S, Blom AW, Khunti K PMID: 28718029 PMCID: PMC5591345 DOI: 10.1007/s10654-017-0277-4 Abstract Evolving debate suggests that C-reactive protein (CRP) might be associated with the development of venous thromboembolism (VTE); however, the evidence is conflicting. We aimed to assess the prospective association of CRP with VTE risk. C-reactive protein was measured in [...]

Auhtors: Yuan X, Zhang J, Li D, Mao Y, Mo F, Du W, Ma X PMID: 28698008 DOI: 10.1016/j.ygyno.2017.07.007 Abstract Objective: The role of tumor-associated macrophages (TAMs) in tumor microenvironment remains controversial due to the two different polarized subsets of TAMs. Here, we performed a meta-analysis to evaluate the correlation between subpopulations of TAMs and [...]