Authors: Pappa S, Barmparessou Z, Sakka E, Sakkas N, Pappas A PMID: 35330485 PMCID: PMC8950533 DOI: 10.3390/jpm12030486 Abstract Evidence to date suggests that a significant proportion of COVID-19 patients experience adverse psychological outcomes and neuropsychiatric complications. The aim of this study was to evaluate the effect of SARS-CoV-2 infection and subsequent hospitalization on the mental [...]

Authors: Marforio TD, Mattioli EJ, Zerbetto F, Calvaresi M PMID: 35335283 PMCID: PMC8955646 DOI: 10.3390/molecules27061916 Abstract The persistency of COVID-19 in the world and the continuous rise of its variants demand new treatments to complement vaccines. Computational chemistry can assist in the identification of moieties able to lead to new drugs to fight the disease. [...]

Authors: Cabral-Marques O, Halpert G, Schimke LF, Ostrinski Y, Vojdani A, Lattin MT PMID: 35264564 PMCID: PMC8907309 DOI: 10.1038/s41467-022-28905-5 Abstract COVID-19 shares the feature of autoantibody production with systemic autoimmune diseases. In order to understand the role of these immune globulins in the pathogenesis of the disease, it is important to explore the autoantibody spectra. [...]

Authors: Ioannou GN, Locke E, Green PK, Berry K DOI: https://doi.org/10.1016/j.eclinm.2022.101326 Abstract Background mRNA COVID-19 vaccines manufactured by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) have been shown to be efficacious but have not been compared in head-to-head clinical trials. Methods We designed this observational study to emulate a target trial of COVID-19 vaccination by BNT162b2 versus [...]

Authors: Puskarich MA, Ingraham NE, Merck LH, Driver BE, Wacker DA, Black LP PMID: 35294537 PMCID: PMC8928006 DOI: 10.1001/jamanetworkopen.2022.2735 Abstract Importance: SARS-CoV-2 viral entry may disrupt angiotensin II (AII) homeostasis, contributing to COVID-19 induced lung injury. AII type 1 receptor blockade mitigates lung injury in preclinical models, although data in humans with COVID-19 remain mixed. [...]

Authors: Oaklander AL, Mills AJ, Kelley M, Toran MK PMID: 35232750 PMCID: PMC8889896 DOI: 10.1212/NXI.0000000000001146 Abstract Background and objectives: Recovery from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appears exponential, leaving a tail of patients reporting various long COVID symptoms including unexplained fatigue/exertional intolerance and dysautonomic and sensory concerns. Indirect evidence links long COVID [...]

Authors: Ahmed A, Ghit A, Houjak A, Elkazzaz M DOI: 10.5772/intechopen.102923 Abstract Zinc is a trace metal ion that has a role in both physiological and pathological processes, making it one of the most common and necessary components involved in brain function. Besides, zinc is required for cell proliferation control in a variety of mechanisms, [...]

Authors: Zhao Y, Jia M, Chen W, Liu Z PMID: 35218914 DOI: 10.1016/j.freeradbiomed.2022.02.021 Abstract Intermittent fasting (IF) has been studied for its effects on lifespan and the prevention or delay of age-related diseases upon the regulation of metabolic pathways. Mitochondria participate in key metabolic pathways and play important roles in maintaining intracellular signaling networks that [...]

Authors: Nguyen B, Tosti A PMID: 35224518 PMCID: PMC8860672 DOI: 10.1016/j.jdin.2022.02.006 Abstract Background: COVID-19 is associated with androgenetic alopecia (AGA), telogen effluvium (TE), and alopecia areata (AA). No studies have analyzed the aggregate data to date. Objective: We conducted a systematic review to characterize the types, incidence, timing, and clinical outcomes of COVID-19-associated alopecia. Methods: [...]

Auhtors: Kumari N, Choi SH PMID: 35183252 PMCID: PMC8857848 DOI: 10.1186/s13046-022-02272-x Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and [...]