Auhtors: Gyori D, Lim EL, Grant FM, Spensberger D, Roychoudhuri R, Shuttleworth SJ, et al. PMID: 29875321 PMCID: PMC6124419 DOI: 10.1172/jci.insight.120631 Abstract Redundancy and compensation provide robustness to biological systems but may contribute to therapy resistance. Both tumor-associated macrophages (TAMs) and Foxp3+ regulatory T (Treg) cells promote tumor progression by limiting antitumor immunity. Here we [...]

Authors: Servy EJ, Jacquesson-Fournols L, Cohen M, Menezo YJ PMID: 29882091 PMCID: PMC6086798 DOI: 10.1007/s10815-018-1225-2 Abstract Purpose: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. In these couples, high doses [...]

Authors: Beljanski S Abstract A new breakthrough book, Winning the War on Cancer:The Epic Journey Towards a Natural Cure reveals the visionary discoveries of a French scientist whose suppressed research led to improvements in the prevention and treatment of cancer...naturally and without toxicity.This book is a "story within a story" as through its pages, Sylvie [...]

Auhtors: Kelly P, Williamson C, Niven AG, Hunter R, Mutrie N, Richards J PMID: 29858467 DOI: 10.1136/bjsports-2017-098827 Abstract Background/objectives: Walking has well-established positive relationships with, and effects on, physical health. In contrast, while poor mental health contributes substantially to global health burden, an overview of the benefits from walking has not previously been published. We [...]

Authors: Mutz J, Edgcumbe DR, Brunoni AR, Fu CH PMID: 29763711 DOI: 10.1016/j.neubiorev.2018.05.015 Abstract We examined the efficacy and acceptability of non-invasive brain stimulation in adult unipolar and bipolar depression. Randomised sham-controlled trials of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and theta-burst stimulation (TBS), without co-initiation of another treatment, were included. We [...]

Authors: Saba A, Vaidya PJ, Chavhan VB, Achlerkar A, Leuppi J PMID: 32476885 PMCID: PMC7170064 DOI: 10.36141/svdld.v35i1.6393 Abstract There are no specific data on the management of pulmonary fibrosis post-H1N1 ARDS. We present the cases of three patients who responded positively to treatment with pirfenidone, azithromycin and prednisolone. Three males, aged 40, 45 and 59 [...]

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Auhtors: Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, et al. PMID: 29657030 PMCID: PMC5932217 DOI: 10.1016/j.cmet.2018.03.002 Abstract Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated [...]

Auhtors: Blum A, Wang P, Zenklusen JC PMID: 29625059 DOI: 10.1016/j.cell.2018.03.059 Abstract This SnapShot provides a list of the tumor types characterized by The Cancer Genome Atlas (TCGA) program. Key findings shown are the most relevant discoveries described in each marker paper for the tumor type. Keywords: cancer, tumors Source: https://pubmed.ncbi.nlm.nih.gov/29625059/ Archive: https://archive.ph/REF1b [...]

Auhtors: Zhang P, Li H, Tan X, Chen L, Wang S PMID: 29618465 DOI: 10.1158/1055-9965.EPI-17-0936 Abstract Background: Preclinical data suggest that metformin may reduce breast cancer incidence and improve cancer prognosis. However, the current evidence in observational studies is inconclusive. A systematic review and meta-analysis was conducted to assess the effect of metformin on the [...]