Auhtors: Sharabi A, tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC PMID: 30310234 DOI: 10.1038/nrd.2018.148 Abstract Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In patients with systemic or organ-specific autoimmune diseases or those receiving transplanted organs, Treg cells are compromised. Approaches to strengthen Treg cell function, either by expanding [...]

Authors: Brononi AR, Sampaio-Junior B, Moffa AH, Aparicio L, Gordon P, Klein I et al. PMID: 30328957 PMCID: PMC6781710 DOI: 10.1590/1516-4446-2017-0018 Abstract Objective: Noninvasive brain stimulation (NIBS) techniques, such as transcranial direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS), are increasingly being used to treat mental disorders, particularly major depression. The aim of [...]

Authors: Stephenson E, Hooper MH, Marik PE DOI:https://doi.org/10.1016/j.chest.2018.08.232 Abstract PURPOSE: The use of intravenous vitamin C for sepsis is increasing. Vitamin C interferes with point-of-care (POC) glucose monitoring devices that use the glucose-dehydrogenase method of testing (e.g. Accu-Chek, Roche, Indianapolis, IN). Spuriously elevated POC glucose levels have been reported in patients with burns after large [...]

Authors: Hadanny A, Abbott S, Suzin G, Bechor Y, Efrati S PMID: 30269074 PMCID: PMC6169752 DOI: 10.1136/bmjopen-2018-023387 Abstract Objectives: The aim of the study is to evaluate the effect of hyperbaric oxygen therapy (HBOT) in participants suffering from chronic neurological deficits due to traumatic brain injury (TBI) of all severities in [...]

Authors: Toljan K, Vrooman B PMID: 30248938 PMCID: PMC6313374 DOI: 10.3390/medsci6040082 Abstract Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 [...]

Cutaneous adverse reactions to medications are extremely common and display characteristic clinical morphology. A fixed drug eruption is a cutaneous adverse drug reaction due to type IV or delayed cell-mediated hypersensitivity. Ivermectin, a broad-spectrum anti-parasitic compound, has been an essential component of public health campaigns targeting the control of two devastating neglected tropical diseases: onchocerciasis (river blindness) and lymphatic filariasis.

Auhtors: Liu Z, Peng Q, Li Y, Gao Y PMID: 30103844 PMCID: PMC6177506 DOI: 10.5483/BMBRep.2018.51.9.114 Abstract Cisplatin is one of the most effective chemotherapeutic drugs used in the treatment of HCC, but many patients will ultimately relapse with cisplatin-resistant disease. Used in combination with cisplatin, resveratrol has synergistic effect of increasing chemosensitivity of cisplatin in [...]

Auhtors: Awad RM, De Vlaeminck Y, Maebe J, Goyvaerts C, Breckpot K PMID: 30233579 PMCID: PMC6127274 DOI: 10.3389/fimmu.2018.01977 Abstract Tumor cells frequently produce soluble factors that favor myelopoiesis and recruitment of myeloid cells to the tumor microenvironment (TME). Consequently, the TME of many cancer types is characterized by high infiltration of monocytes, macrophages, dendritic cells [...]

Auhtors: Gaziano JM, Brotons C, Coppolecchia R, Cricelli C, Darius H, Gorelick PB, et al. PMID: 30158069 PMCID: PMC7255888 DOI: 10.1016/S0140-6736(18)31924-X Abstract Background: The use of aspirin in the primary prevention of cardiovascular events remains controversial. We aimed to assess the efficacy and safety of aspirin versus placebo in patients with a moderate estimated risk [...]

Authors: Plantone D, Koudriavtseva T PMID: 29737455 DOI: 10.1007/s40261-018-0656-y Abstract The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), [...]