Auhtors: Khadge S, Sharp JG, Mcguire TR, Thiele GM, Black P, Dirusso C, et al. PMID: 30447537 PMCID: PMC6322683 DOI: 10.1016/j.intimp.2018.10.026 Abstract Rodent and clinical studies have documented that myeloid cell infiltration of tumors is associated with poor outcomes, neutrophilia and lymphocytopenia. This contrasts with increased lymphocyte infiltration of tumors, which is correlated with improved [...]

Authors: Marik PE PMID: 30441816 doi: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, Ascorbic Acid [...]

Authors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 doi: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Nieman DC, Kay CD, Rathore AS, Grace MH, Strauch RC. PMID: 30423955 PMCID: PMC6267437 DOI: 10.3390/nu10111718 Abstract Using a randomized, double-blinded, placebo-controlled, parallel group design, this investigation determined if the combination of two weeks of flavonoid supplementation (329 mg/day, quercetin, anthocyanins, flavan-3-ols mixture) and a 45-minute walking bout (62.2 ± 0.9% VO2max (maximal oxygen [...]

Authors: Pistollato F, Masias M, Agudo P, Giampieri F. PMID: 30381840 DOI: 10.1111/nyas.13980 Abstract About 1 of 10 women, particularly those older than 60 years of age, shows some degree of thyroid hormone deficiency. Thyroid diseases are generally characterized by perturbations of thyroid signaling homeostasis. The most common examples of thyroid diseases include hypothyroidism, hyperthyroidism, [...]

Auhtors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 DOI: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Marik PE PMID: 30312231 DOI: 10.1097/CCM.0000000000003336 Keywords: delirium, sepsis, septic shock, thiamine, Wernicke’s Source: https://journals.lww.com/ccmjournal/citation/2018/11000/thiamine__an_essential_component_of_the_metabolic.23.aspx Archive: https://archive.ph/z98Jx

Authors: Woolum JA, Abner EL, Kelly A, Thompson Bastin ML, Morris PE, Flannery AH. PMID: 30028362 DOI: 10.1097/CCM.0000000000003311 Abstract Objectives: Mounting evidence has shown that critically ill patients are commonly thiamine deficient. We sought to test the hypothesis that critically ill patients with septic shock exposed to thiamine would demonstrate improved lactate clearance and more [...]

Auhtors: Zhang Y, Fan Y, Huang S, Wang G, Han R, Lei F, et al. PMID: 30259603 PMCID: PMC6272120 DOI: 10.1111/cas.13808 Abstract Thymoquinone (TQ, 2-methyl-5-isopropyl-1,4-benzoquinone), a bioactive constituent extracted from the seeds of Nigella sativa, has been proved to exert anti-tumor efficiency in various cancers. Autophagy is a self-digestion phenomenon, and its role in tumor [...]

Auhtors: Vallianou NG, Stratigou T, Tsagarakis S PMID: 30342053 DOI: 10.1016/j.diabres.2018.10.008 Abstract Alterations in the diversity or structure of gut microbiota known as dysbiosis, may affect metabolic activities, resulting in metabolic disorders, such as obesity and diabetes. The development of more sophisticated methods, such as metagenomics sequencing, PCR-denaturing gradient gel electrophoresis, microarrays and fluorescence in [...]