Auhtors: Antures F, Erustes AG, Costa AJ, Nascimento AC, Bincoletto C, Ureshino RP, Smali SS PMID: 30540126 PMCID: PMC6257056 DOI: 10.6061/clinics/2018/e814s Abstract Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to [...]

Auhtors: Yang T, Qiao Y, Xiang S, Li W, Gan Y, Chen Y PMID: 30484859 DOI: 10.1002/ijc.31955 Abstract Epidemiological studies have explored the relationship between work stress and the risk of cancer, but it remains unclear on whether work stress could increase the risk of cancer, or by other factors such as smoking and physical [...]

Authors: Pantziarka P, Verbaanderd C, Sukhatme V, Rica C, I, Crispino S, Gyawali B, et al. PMID: 30679953 PMCID: PMC6345075 DOI: 10.3332/ecancer.2018.886 Abstract Repurposing is a drug development strategy that seeks to use existing medications for new indications. In oncology, there is an increased level of activity looking at the use of non-cancer drugs as [...]

Auhtors: Butti R, Gunasekaran VP, Kumar TVS, Banerjee P, Kundu GC PMID: 30529656 DOI: 10.1016/j.biocel.2018.12.001 Abstract Breast cancer remains to be a dreadful disease even with several advancements in radiation and chemotherapies, owing to the drug resistance and tumor relapse caused by breast cancer stem cells. Cancer stem cells are a minute population of cells [...]

Auhtors: Jin F, Xie T, Huang X, Zhao X PMID: 31070539 PMCID: PMC6319470 DOI: 10.1080/13880209.2018.1548627 Abstract Context: Berberine is used in traditional Chinese medicine for thousands of years with recent reports of its anticancer activity. Objective: To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway. Materials and methods: [...]

Authors: Sabel BA, Flammer J, Merabet LB PMID: 30412515 PMCID: PMC6294586 DOI: 10.3233/RNN-180880 Abstract Vision loss due to ocular diseases such as glaucoma, optic neuropathy, macular degeneration, or diabetic retinopathy, are generally considered an exclusive affair of the retina and/or optic nerve. However, the brain, through multiple indirect influences, has also a major impact on [...]

Auhtors: Advani SM, Advani PG, VonVille HM, Jafri SH PMID: 30482179 PMCID: PMC6260745 DOI: 10.1186/s12885-018-5080-4 Abstract Background: Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline. Management of cachexia involves addressing multiple underlying biological mechanisms. Previous review on pharmacological management of cancer cachexia [...]

Auhtors: Chen Y, Tan F, Wei L, Li X, Lyu Z, Feng X, et al. PMID: 30463535 PMCID: PMC6249821 DOI: 10.1186/s12885-018-5025-y Abstract Background: The effect of sleep duration on cancer risk remains controversial. We aimed to quantify the available evidence on this relationship using categorical and dose-response meta-analyses. Methods: Population-based cohort studies and case-control studies [...]

Authors: Becerra-Diaz M, Strickland AB, Keselman A, Heller NM PMID: 30305328 PMCID: PMC6219904 DOI: 10.4049/jimmunol.1800352 Abstract Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar macrophages (AM). The number of M2 macrophages in the airway correlates [...]

Auhtors: Marik PE PMID: 30441816 PMCID: PMC6265973 DOI: 10.3390/nu10111762 Abstract Sepsis is a devastating disease that carries an enormous toll in terms of human suffering and lives lost. Over 100 novel pharmacologic agents that targeted specific molecules or pathways have failed to improve the outcome of sepsis. Preliminary data suggests that the combination of Hydrocortisone, [...]