Authors: Santos HO, Howell S, Earnest CP, Teixeira FJ PMID: 31707063 DOI: 10.1016/j.pcad.2019.11.001 Abstract In recent years, health professionals and laypersons have disseminated misinformation regarding the consumption of coconut oil. Those encouraging the supplementation of coconut oil argue that it provides health benefits and protective cardiovascular effects. Our article examines the effects of coconut oil [...]

Authors: Levine TD, Kafaie J, Zeidman LA, Saperstein DS, Bland RJ PMID: 31650561 DOI: 10.1002/mus.26748 Abstract Introduction: Causes of small-fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor-3 (FGFR-3), and immunoglobulin M (IgM) vs trisulfated heparan disaccharide (TS-HDS) in cryptogenic [...]

Authors: Nieman DC, Simonson A, Sakaguchi CA, Sha W, Blevins T. PMID: 31694152 doi: 10.3390/nu11112665 Abstract This randomized, double-blinded, crossover study measured the acute effect of ingesting a mixed flavonoid-caffeine (MFC) supplement compared to placebo (PL) on energy expenditure (EE) and fat oxidation (FATox) in a metabolic chamber with premenopausal women (n = 19, mean [...]

Authors: Bawazeer MA, Theoharides TC PMID: 31669588 DOI: 10.1016/j.ejphar.2019.172760 Abstract Mast Cells (MCs) are critical for allergic reactions but also play important roles in inflammation, following stimulation by non-allergic triggers such as cytokines. Upon stimulation, MCs secrete numerous newly synthesized mediators, but the mechanism of the release of chemokines, which are important in the pathogenesis [...]

Auhtors: Tian Y, Song W, Li D, Cai L, Zhao Y PMID: 31802896 PMCID: PMC6802539 DOI: 10.2147/OTT.S213043 Abstract Resveratrol, as a natural product compound, has been recently attracted much attention for its potent effects on cancer. Cancer is a serious disease threatening human survival and social development. Autophagy is a cellular pathway to realize the [...]

Authors: Gutierrez S, Svahn SL, Johansson ME PMID: 31614433 PMCID: PMC6834330 DOI: 10.3390/ijms20205028 Abstract Alterations on the immune system caused by omega-3 fatty acids have been described for 30 years. This family of polyunsaturated fatty acids exerts major alterations on the activation of cells from both the innate and the adaptive immune system, although [...]

Authors: Fowler AA, Truwit JD, Hite D, Morris PE, DeWilde C, Priday A et al. PMID: 31573637 PMCID: PMC6777268 DOI: 10.1001/jama.2019.11825 Abstract Importance: Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS). Objective: To determine the effect of intravenous vitamin C infusion [...]

Authors: Verbeke R, Lentacker I, Smedt SC, DeWitte H DOI:10.1016/j.nantod.2019.100766 Abstract In the early nineties, pioneering steps were taken in the use of mRNA as a therapeutic tool for vaccination. In the following decades, an improved understanding of the mRNA pharmacology, together with novel insights in immunology have positioned mRNA-based technologies as next-generation vaccines. This [...]

Authors: Brouwer WP, Duran S, Kuijper M, Inc C PMID: 31533846 PMCID: PMC6749645 DOI: 10.1186/s13054-019-2588-1 Abstract Background and aims: Innovative treatment modalities have not yet shown a clinical benefit in patients with septic shock. To reduce severe cytokinaemia, CytoSorb as an add-on to continuous renal replacement therapy (CRRT) showed promising results in case reports. However, [...]

Auhtors: Gok Metin Z, Karadas C, Izgu N, Ozdemir L, Demirci U PMID: 31520865 DOI: 10.1016/j.ejon.2019.09.003 Abstract Purpose: This study aimed to investigate the effects of progressive muscle relaxation (PMR) and mindfulness meditation (MM) on fatigue, coping styles, and quality of life (QOL) in patients with early breast cancer receiving adjuvant paclitaxel. Methods: The participants [...]