Auhtors: Campos-Carrillo A, Weitzel JN, Sahoo P, Rockne R, Mokhnatkin JV, Murtaza M, et al. PMID: 31863816 PMCID: PMC6957244 DOI: 10.1016/j.pharmthera.2019.107458 Abstract Circulating tumor DNA holds substantial promise as an early detection biomarker, particularly for cancers that do not have currently accepted screening methodologies, such as ovarian, pancreatic, and gastric cancers. Many features intrinsic to [...]

Authors: de Moreuil C, Alavi Z, Pasquier E PMID: 31633823 PMCID: PMC6983516 DOI: 10.1111/bcp.14131 Abstract Recurrent miscarriage (RM) and vasculoplacental disorders, such as preeclampsia (PE), affect women of childbearing age worldwide. Vascular endothelial dysfunction and immunological impairment are associated with both RM and PE. To date, there is no effective or optimal therapeutic approach for [...]

Auhtors: Fan CS, Chen LL, Hsu TA, Chen CC, Chua KV, Li CP, Huang TS PMID: 31847880 PMCID: PMC6918594 DOI: 10.1186/s13045-019-0826-2 Abstract Background: Endothelial-to-mesenchymal transition (EndoMT) can provide a source of cancer-associated fibroblasts which contribute to desmoplasia of many malignancies including pancreatic ductal adenocarcinoma (PDAC). We investigated the clinical relevance of EndoMT in PDAC, and [...]

Auhtors: Raffin C, Vo LT, Bluestone JA PMID: 31811270 PMCID: PMC7814338 DOI: 10.1038/s41577-019-0232-6 Abstract Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of Treg cells and describe new efforts in Treg cell engineering [...]

Authors: Huang X, Han S, Liu x, Wang T, Xu H PMID: 32010252 PMCID: PMC6966138 DOI: 10.3892/etm.2019.8285 Abstract Sepsis commonly progresses to disseminated intravascular coagulation and induces the activation of heparanase (HPA) and the shedding of endothelial glycocalyx constituents, including syndecan-1 (SDC-1) and heparan sulphate (HS). However, the degradation of glycocalyx and its association with [...]

Auhtors: Li X, Liu R, Su X, Pan Y, Han X, Shao C, Shi Y PMID: 31805946 PMCID: PMC6894344 DOI: 10.1186/s12943-019-1102-3 Abstract Cancer immunotherapies that engage immune cells to fight against tumors are proving to be powerful weapons in combating cancer and are becoming increasingly utilized in the clinics. However, for the majority of patients [...]

Auhtors: Lundt A, Jentschke E PMID: 30791735 PMCID: PMC7240880 DOI: 10.1177/1534735418822096 Abstract Background: Symptoms of anxiety, depression, and cancer-related fatigue are commonly associated with cancer. Cancer patients increasingly use complementary and alternative treatments, such as yoga, to cope with psychological and physical impairments. In the present article, long-term changes of anxiety, depression, and fatigue in [...]

Authors: Shukla AM, Shukla AW PMID: 31844421 PMCID: PMC6905642 DOI: 10.7573/dic.2019-9-1 Abstract Several experimental and clinical studies have transformed the traditional antimalarial role of chloroquine (CHQ) and related structural analogues to potent therapeutic agents for a host of nonmalarial indications. The expanding clinical applicability for these drugs includes rheumatological and cardiovascular disorders (CVD), chronic kidney [...]

Authors: Howell AP, Parrett JL, Malcom DR PMID: 31766883 PMCID: PMC8256056 DOI: 10.1177/1932296819889638 Abstract Background: Intravenous vitamin C therapy has been associated with reduced mortality in patients with sepsis. Of potential concern with this therapy are falsely elevated point-of-care (POC) blood glucose values vs laboratory analyzed (LA) readings. The purpose of this study was to [...]

Auhtors: Agrawal S, Wozniak M, Luc M, Makuch S, Pielka E, Agrawal AK, et al. PMID: 31719636 PMCID: PMC6851401 DOI: 10.1038/s41598-019-53145-x Abstract The present state of cancer chemotherapy is unsatisfactory. New anticancer drugs that marginally improve the survival of patients continue to be developed at an unsustainably high cost. The study aimed to elucidate the [...]