About 3·7 billion doses of ivermectin have been distributed in mass drug administration (MDA) campaigns globally over the past 30 years. At 10–100 times higher than current human doses, ivermectin is a known teratogen in mammals. During these campaigns with recommended doses, pregnant women might be inadvertently exposed. We therefore aimed to evaluate the existing evidence for serious and non-serious adverse events after ivermectin exposure in pregnant women.

Authors: Nicolas P, Maia MF, Bassat Q, Kobylinski KC, Monteiro W Abstract Background About 3·7 billion doses of ivermectin have been distributed in mass drug administration (MDA) campaigns globally over the past 30 years. At 10–100 times higher than current human doses, ivermectin is a known teratogen in mammals. During these campaigns with recommended [...]

To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection.

Auhtors: de Cabo R, Mattson MP. PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: intermittent fasting, health, [...]

Authors: deCabo R, Mattson MP PMID: 31881139 DOI: 10.1056/NEJMra1905136 Abstract Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, increased longevity, and a decreased incidence of diseases, including cancer and obesity. Keywords: fasting, intermittent fasting, health [...]

Auhtors: Salve J, Pate S, Debnath K, Langade D PMID: 32021735 PMCID: PMC6979308 DOI: 10.7759/cureus.6466 Abstract Background Stress, anxiety and impeded sleep are a frequent feature of life in modern societies. Across socio-economic strata, stress, anxiety and ineffective sleep detract from healthful living and serve as precursors of various ailments. The use of herbs to [...]

Authors: Colunga Biancatelli RM, Berrill M, Marik PE PMID: 31852327 DOI: 10.1080/14787210.2020.1706483 Abstract There is a growing interest in the administration of vitamin C beyond the treatment of hypovitaminosis C in malnourished patients. This has been driven by a 2016 ‘before-after’ study which suggested a substantial survival benefit from a protocol that included hydrocortisone, ascorbic [...]

Authors: Liu J, Liang H, Chen C, Wang X, Qu F, Wang H PMID: 31755894 PMCID: PMC6900471 DOI: 10.1042/BSR20192489 Abstract Glioma is one of the most common types of primary brain tumors. Ivermectin (IVM), a broad-spectrum antiparasitic drug, has been identified as a novel anticancer agent due to its inhibitory effects on the proliferation of [...]

Auhtors: Ambrosone CB, Zirpoli GR, Hutson AD, McCann WE, McCann SE, Barlow WE, et al. PMID: 31855498 PMCID: PMC7062457 DOI: 10.1200/JCO.19.01203 Abstract Purpose: Despite reported widespread use of dietary supplements during cancer treatment, few empirical data with regard to their safety or efficacy exist. Because of concerns that some supplements, particularly antioxidants, could reduce the [...]

Auhtors: Liu W, Wang W, Wang X, Xu C, Zhang N, Di W PMID: 31866467 DOI: 10.1016/j.canlet.2019.12.024 Abstract Despite the high response rate after surgery and platinum-combination chemotherapy, treatment of ovarian cancer remains challenging due to tumor recurrence and metastasis. Tumor-associated macrophages (TAMs) have been linked to cancer progression and metastasis. However, the impact of [...]