Authors: Seifirad S PMID: 32575019 PMCID: PMC7297676 DOI: 10.1016/j.mehy.2020.110005 Abstract Cytokine storm, multiorgan failure, and particularly acute respiratory distress syndrome (ARDS) is the leading cause of mortality and morbidity in patients with COVID-19. A fulminant ARDS kills the majority of COVID-19 victims. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is [...]

Authors: Seifirad S PMID: 32575019 PMCID: PMC7297676 DOI: 10.1016/j.mehy.2020.110005 Abstract Cytokine storm, multiorgan failure, and particularly acute respiratory distress syndrome (ARDS) is the leading cause of mortality and morbidity in patients with COVID-19. A fulminant ARDS kills the majority of COVID-19 victims. Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone), is a novel anti-fibrotic agent with trivial adverse effects. Pirfenidone is [...]

Auhtors: AlGhamdi AA, Mohammed MRS, Zamzami MA, Al-Malki AL, Qari MH, Khan MI, Choudhry H PMID: 32560283 PMCID: PMC7353463 DOI: 10.3390/nu12061792 Abstract Thymoquinone (TQ), a naturally occurring anticancer compound extracted from Nigella sativa oil, has been extensively reported to possess potent anti-cancer properties. Experimental studies showed the anti-proliferative, pro-apoptotic, and anti-metastatic effects of TQ on [...]

Auhtors: Fu X, Tan T, Liu P PMID: 32606952 PMCID: PMC7305821 DOI: 10.2147/CMAR.S253345 Abstract Cancer is the leading cause of death, placing a substantial global health burden. The development of the most effective treatment regimen is the unmet clinical need for cancer. Inflammation plays a role in tumorigenesis and progression, and anti-inflammation may be a [...]

Authors: Reiter RJ, Sharma R, Ma Q, Liu C, Manucha W, Abreu-Gonzalez P DOI: https://doi.org/10.32794/mr11250068 Abstract COVID-19 has infected hundreds of thousands and killed tens of thousands of people worldwide and it continues to ravage societies as well as fiscal and economic stability of several countries. Currently, several drugs that were designed for other [...]

Authors:Castillo RR, Quizon GR, Juco MJ, Roman AD, de Leon DG, Punzalan FE et al. DOI: https://doi.org/10.32794/mr11250063 Abstract Treatment for coronavirus disease 2019 (COVID19) pneumonia remains empirical and the search for therapies that can improve outcomes continues. Melatonin has been shown to have anti-inflammatory, antioxidant, and immune-modulating effects that may address key pathophysiologic mechanisms in [...]

Coronavirus disease 19 (COVID-19) is a viral disease caused by the new coronavirus SARS-CoV-2. Like other coronaviral infections, SARS-CoV-2 causes oxidative and ER stress triggering cellular response pathways, mainly PERK and IRE1 branches of the UPR.

Auhtors: Burn J, Sheth H, Elliott F, Reed L, Macrae F, Mecklin JP, et al. PMID: 32534647 PMCID: PMC7294238 DOI: 10.1016/S0140-6736(20)30366-4 Abstract Background: Lynch syndrome is associated with an increased risk of colorectal cancer and with a broader spectrum of cancers, especially endometrial cancer. In 2011, our group reported long-term cancer outcomes (mean follow-up 55·7 [...]

Auhtors: Babic A, Sasamoto N, Rosner BA, Tworoger SS, Jordan SJ, Risch HA, et al. PMID: 32239218 PMCID: PMC7118668 DOI: 10.1001/jamaoncol.2020.0421 Abstract Importance: Breastfeeding has been associated with a reduced risk of epithelial ovarian cancer in multiple studies, but others showed no association. Whether risk reduction extends beyond that provided by pregnancy alone or differs [...]

Authors: Rajter JC, Sherman MS, Fatteh N, Vogel F, Sacks J, Rajter JJ. doi: https://doi.org/10.1101/2020.06.06.20124461 Abstract Importance No therapy to date has been shown to improve survival for patients infected with SARS-CoV-2. Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in vitro but clinical response has not been previously evaluated. Objective To determine [...]