New research provides evidence of an impaired vitamin D gene signature in CD4+ T cells in patients with severe COVID-19. Mechanistically, it is shown that vitamin D alters the epigenetic landscape of CD4+ T cells, as well as inducing key transcription factors such as STAT3, BACH2 and JUN that reduce levels of IFN-γ and increase IL-10. These changes generate pro-resolving TH1 cells that may be beneficial in resolving or preventing severe COVID-19.

Authors: Gorial FI, Mashhadani S, Sayaly HM, Dakhil BD, AlMashhadani MM. doi: https://doi.org/10.1101/2020.07.07.20145979 Abstract Background To date no effective therapy has been demonstrated for COVID-19. In vitro, studies indicated that ivermectin (IVM) has antiviral effect. Objectives To assess the effectiveness of ivermectin (IVM) as add-on therapy to hydroxychloroquine (HCQ) and azithromycin (AZT) in treatment of [...]

Authors: Santamarina MG, Boisier D, Contreras R, Baque M, Volpacchio M PMID: 32631389 PMCID: PMC7338110 DOI: 10.1186/s13054-020-03125-9 Abstract In December 2019, a novel human coronavirus, SARS-CoV-2, was detected in the city of Wuhan, China, which since then has expanded throughout the world and caused a pandemic coronavirus disease (COVID-19). SARS-CoV-2 binds to angiotensin-converting enzyme 2 [...]

Authors: Francone M, Lafrate F, Masci GM, Coco S, Cilia F, Manganaro L et al. PMID: 32623505 PMCID: PMC7334627 DOI: 10.1007/s00330-020-07033-y Abstract Objectives: To correlate a CT-based semi-quantitative score of pulmonary involvement in COVID-19 pneumonia with clinical staging of disease and laboratory findings. We also aimed to investigate whether CT findings may be predictive of [...]

Auhtors: Szurpnicka A, Kowalczuk A, Szterk A PMID: 32621089 PMCID: PMC7340679 DOI: 10.1007/s12272-020-01247-w Abstract Mistletoe has been used as treatment of many diseases in traditional and folk medicine. To date, anticancer, immunomodulatory, cardiac, antidiabetic, hepatoprotective, neuropharmacological, antibacterial and antifungal properties of mistletoe extracts have been studied the most. In this review, we summarized in vitro [...]

Authors: Isidori AM, Giannetta E, Pofi R, Venneri MA, Gianfrilli D, Campolo F PMID: 32526061 PMCID: PMC7307129 DOI: 10.1111/andr.12837 Abstract Background: A pandemic outbreak of COVID-19 has been sweeping the world since December. It begins as a respiratory infection that, mainly in men with diabetes or renal impairment, evolves into a systemic disease, with SARDS, [...]

Auhtors: Diorio C, Kelly KM, Afungchwi GM, Ladas EJ, Marjerrison S PMID: 32614139 DOI: 10.1002/pbc.28324 Abstract Traditional and complementary medicine (T&CM) strategies are commonly used by pediatric cancer patients. Nutritional approaches to T&CM include bioactive compounds, supplements, and herbs as well as dietary approaches. Pediatric cancer patients and their families commonly request and use nutritional [...]

Authors: Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S PMID: 32167524 PMCID: PMC7070509 DOI: 10.1001/jamainternmed.2020.0994 Abstract Importance: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been [...]

Authors: Zeh HJ, Bahary N, Boone BA, Singh AD, Normolle Dp, Hogg ME PMID: 32156749 PMCID: PMC8086597 DOI: 10.1158/1078-0432.CCR-19-4042 Abstract Purpose: We hypothesized that autophagy inhibition would increase response to chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We performed a randomized controlled trial to assess the autophagy inhibitor hydroxychloroquine in combination with [...]

Authors: Calis Z, Mogulkoc R, Baltaci AK. PMID: 31288717 DOI: 10.2174/1389557519666190617150051 Abstract The inflammatory process in the human body is a physiological response involving many cellular types and mediators. It results in scar formation to separate the damaged area from the surrounding healthy tissue. Because of increased blood-brain barrier permeability following inflammation, leukocytes infiltrate the [...]