Authors: Schurink B, Roos E, Radonic T, Barbe E, Bouman CS DOI:https://doi.org/10.1016/S2666-5247(20)30144-0 Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) targets multiple organs and causes severe coagulopathy. Histopathological organ changes might not only be attributable to a direct virus-induced effect, but also the immune response. The aims of this study were to assess the [...]

Authors: Zhang Q, Bastard P, Liu Z, Le Pen J, Chen J, Korol C PMID: 32972995 PMCID: PMC7857407 DOI: 10.1126/science.abd4570 Abstract Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function [...]

Authors:.= Khan MS, Khan MS, Debnath Cr, Nath PN, Mahtab MA. PMID: 33293006 PMCID: PMC7837160 DOI: 10.1016/j.arbres.2020.08.007 Abstract The pandemic coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been spread rapidly worldwide with considerable morbidity and mortality. COVID-19 patients have various clinical presentations: asymptomatic, exhibit mild flu-like symptoms, be [...]

Authors: Kory P, Kanne JP PMID: 32963028 PMCID: PMC7509945 DOI: 10.1136/bmjresp-2020-000724 Abstract Reviews of COVID-19 CT imaging along with postmortem lung biopsies and autopsies indicate that the majority of patients with COVID-19 pulmonary involvement have secondary organising pneumonia (OP) or its histological variant, acute fibrinous and organising pneumonia, both well-known complications of viral infections. Further, [...]

Authors: Ruiz-Irastorza G, Pijoan JI, Bereciatua E, Dunder S, Dominguez J, Garcia-Escudero P PMID: 32960899 PMCID: PMC7508405 DOI: 10.1371/journal.pone.0239401 Abstract Objective: To analyze the effects of a short course of methyl-prednisolone pulses (MP) during the second week of disease (week-2) in patients with severe coronavirus disease 2019 (COVID-19) pneumonia. Methods: Comparative observational study using data [...]

Authors: Andreakos E, Papadaki M, Serhan CN PMID: 32956495 PMCID: PMC7537007 DOI: 10.1111/all.14595 Abstract Coronavirus disease-19 (COVID-19) is a new disease caused by SARS-CoV-2. Since the beginning of 2020, it has become one of the main challenges of our times, causing a high incidence of severe pneumonia, acute respiratory distress syndrome (ARDS), multiorgan failure, and [...]

Auhtors: Hope JR Abstract How does a trained physician beat terminal cancer when he, himself, gets it? · The answer will both shock and surprise you, as it is often NOT the same treatment that physicians prescribe for their patients. · Dr.Hope takes you through successful survival stories of doctor after doctor -and he explains [...]

Coronavirus Disease 2019 (COVID-19) pandemic continues unabated in many parts of the world. In the absence of any definite antiviral therapy except some benefit of remdesivir, there is an ongoing search for effective therapy. Famotidine has been shown to reduce mortality in hospitalized patients in a few studies. We conducted a systematic review on the use of famotidine in COVID-19.

Authors: Arvinte C, Singh M, Marik PE PMID: 32964205 PMCID: PMC7499070 DOI: 10.1016/j.medidd.2020.100064 Abstract Background: The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of [...]

Authors: Zaid Y, Puhm F, Allaeys I, Naya A, Oudghiri M PMID: 32938299 PMCID: PMC7641188 DOI: 10.1161/CIRCRESAHA.120.317703 Abstract Rationale: In addition to the overwhelming lung inflammation that prevails in COVID-19, hypercoagulation and thrombosis contribute to the lethality of subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Platelets are chiefly implicated in thrombosis. Moreover, [...]