Introduction: To compare outcomes in patients hospitalized with coronavirus (COVID-19) receiving famotidine therapy with those not receiving famotidine. Methods: Retrospective, propensity-matched observational study of consecutive COVID-19-positive patients between February 24, 2020, and May 13, 2020.

Authors: Derosa G, Maffioli P, D'Angelo A, Di Pierro F. doi: https://doi.org/10.1002/ptr.6887 Abstract Several months ago, an outbreak of pneumonia of unknown aetiology was detected in Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the Chinese authorities as novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO announced this new disease [...]

Authors: Derosa G, Maffioli P, D'Angelo A, Di Pierro F PMID: 33034398 PMCID: PMC7675685 DOI: 10.1002/ptr.6887 Abstract Several months ago, an outbreak of pneumonia of unknown aetiology was detected in Wuhan City (China) and the aetiological agent of the atypical pneumonia was isolated by the Chinese authorities as novel coronavirus (2019-nCoV or SARS-CoV-2). The WHO [...]

Authors: Moozhipurath RK, Kraft L, Skiera B. PMID: PMC7572372 DOI: 10.1038/s41598-020-74825-z Abstract Prior studies indicate the protective role of Ultraviolet-B (UVB) radiation in human health, mediated by vitamin D synthesis. In this observational study, we empirically outline a negative association of UVB radiation as measured by ultraviolet index (UVI) with the number of COVID-19 deaths. [...]

Authors: Rawson TM, Wilson RC, Holmes A PMID: 32979569 PMCID: PMC7546203 DOI: 10.1016/j.cmi.2020.09.025 Abstract The novel coronavirus disease (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has placed an unprecedented strain on healthcare systems. An emerging concern is the potential impact of the novel coronavirus SARS-CoV-2 pandemic on antimicrobial resistance (AMR). [...]

Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation.

Authors: Cadegiani FA, Goren A, Wambier CG, McCoy J doi: https://doi.org/10.1101/2020.10.05.20206870 Abstract Background While COVID-19 remains largely unclear and mortality continues to raise, early effective approaches prior to complications lack, as well as researches for characterization and therapeutical potential options in actual early COVID-19. Although females seem to be less affected than females, hyperandrogenic (HA) [...]

Authors: Dequin PF, Heming N, Meziani F, Plantefeve G, Voiriot G PMID: 32876689 PMCID: PMC7489432 DOI: 10.1001/jama.2020.16761 Abstract Importance: Coronavirus disease 2019 (COVID-19) is associated with severe lung damage. Corticosteroids are a possible therapeutic option. Objective: To determine the effect of hydrocortisone on treatment failure on day 21 in critically ill patients with severe acute [...]

Authors: Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, et al. PMID: 32876697 PMCID: PMC7489418 DOI: 10.1001/jama.2020.17022 Abstract Importance: Evidence regarding corticosteroid use for severe coronavirus disease 2019 (COVID-19) is limited. Objective: To determine whether hydrocortisone improves outcome for patients with severe COVID-19. Design, setting, and participants: An ongoing adaptive platform trial testing [...]

Authors: Buijsers B, Yanginlar C, de Nooijer A, Grondman I, Jonkman I, Rother N PMID: 33123154 PMCID: PMC7573491 DOI: 10.3389/fimmu.2020.575047 Abstract Reports suggest a role of endothelial dysfunction and loss of endothelial barrier function in COVID-19. It is well established that the endothelial glycocalyx-degrading enzyme heparanase contributes to vascular leakage and inflammation. Low molecular weight [...]