Authors:Green A, Roberts G, Tobery T, Vincent C, Barili M. doi: https://doi.org/10.1101/2020.10.28.359257 Abstract Background saliva is established to contain high counts SARS-CoV-2 virus and contact with saliva droplets, contaminated surfaces or airborne particles are sources of viral transmission. The generation of infective aerosols during clinical procedures is of particular concern. Therefore, a fuller understanding of [...]

Auhtors: Ramgopal S, Aronson PL, Marin JR PMID: 33207160 PMCID: PMC7673886 DOI: 10.5811/westjem.2020.8.47455 Abstract Introduction: Our goal in this study was to estimate rates of emergency department (ED) visits for fever by children <2 years of age, and evaluate frequencies of testing and treatment during these visits. Methods: We performed a cross-sectional study of ED [...]

COVID-19 patients suffer from the lack of curative therapy. Hence, there is an urgent need to try repurposed old drugs on COVID-19. Methods Randomized controlled study on 70 COVID-19 patients (48 mild-moderate, 11 severe, and 11 critical patients) treated with 200ug/kg PO of Ivermectin per day for 2-3 days along with 100mg PO doxycycline twice per day for 5-10 days plus standard therapy; the second arm is 70 COVID-19 patients (48 mild-moderate and 22 severe and zero critical patients) on standard therapy. The time to recovery, the progression of the disease, and the mortality rate were the outcome-assessing parameters.

Authors: Hashim HA, Maulood MF, rasheed AM, Fatak DF, Kabah KK. doi: https://doi.org/10.1101/2020.10.26.20219345 Abstract Objectives COVID-19 patients suffer from the lack of curative therapy. Hence, there is an urgent need to try repurposed old drugs on COVID-19. Methods Randomized controlled study on 70 COVID-19 patients (48 mild-moderate, 11 severe, and 11 [...]

Authors: Bernheim A, Mei X, Huang M, Yang Y, Fayad ZA, Zhang N et al. PMID: 33142125 PMCID: PMC7585632 DOI: 10.1016/j.clinimag.2020.10.035 Abstract Objectives: We performed a systematic review and meta-analysis of the prevalence of chest CT findings in patients with confirmed COVID-19 infection. Methods: Systematic review of the literature was performed using PubMed, Scopus, Embase, [...]

Authors: Woodruff MC, Ramoneli RP, Lee FE, Sanz I doi: https://doi.org/10.1101/2020.10.21.20216192 Abstract Severe SARS-CoV-2 infection is linked to the presence of autoantibodies against multiple targets, including phospholipids and type-I interferons. We recently identified activation of an autoimmune-prone B cell response pathway as correlate of severe COVID-19, raising the possibility of de novo autoreactive antibody production [...]

Authors: Agarwal A, Mukherjee A, Kumar G, Chatterjee P, Bhatnager T PMID: 33093056 PMCID: PMC7578662 DOI: 10.1136/bmj.m3939 Abstract Objective: To investigate the effectiveness of using convalescent plasma to treat moderate coronavirus disease 2019 (covid-19) in adults in India. Design: Open label, parallel arm, phase II, multicentre, randomised controlled trial. Setting: 39 [...]

Authors: Stone JH, Frigault MJ, Sterling-Boyd NJ, Fernandes AD, Harvey FL PMID: 33085857 PMCID: PMC7646626 DOI: 10.1056/NEJMoa2028836 Abstract Background: The efficacy of interleukin-6 receptor blockade in hospitalized patients with coronavirus disease 2019 (Covid-19) who are not receiving mechanical ventilation is unclear. Methods: We performed a randomized, double-blind, placebo-controlled trial involving patients with confirmed severe acute [...]

Authors: Goren A, Wambler CG, Herrera S, McCoy J, Gioia F PMID: 32977363 PMCID: PMC7536996 DOI: 10.1111/jdv.16953 Abstract The COVID-19 pandemic has disproportionally affected men.1 Men infected with SARS-CoV-2 are more than twice as likely to be admitted to the intensive care unit (ICU).2 This disparity in ICU admissions suggests the important role of androgens [...]

Authors: Valizadeh H, Danshina S, Gencer MZ, Ammari A, Sadeghi A, Aslani S. PMID: PMC7574843 DOI: 10.1016/j.intimp.2020.107088 Abstract Background: As an ongoing worldwide health issue, Coronavirus disease 2019 (COVID-19) has been causing serious complications, including pneumonia, acute respiratory distress syndrome (ARDS), and multi-organ failure. However, there is no decisive treatment approach available for this disorder, [...]