Authors: Barbash IJ, Davis BS, Yabes JG, Seymour CW, Angus DC, Kahn JM PMID: 33872042 PMCID: PMC8844885 DOI: 10.7326/M20-5043 Abstract Background: Medicare requires that hospitals report on their adherence to the Severe Sepsis and Septic Shock Early Management Bundle (SEP-1). Objective: To evaluate the effect of SEP-1 on treatment patterns and patient outcomes. Design: Longitudinal [...]

Authors:Seet RC, Quek AM, Ooi DS, Sengupta S, Koo CY. PMID:PMC8056783 DOI: 10.1016/j.ijid.2021.04.035 Abstract Background: We examined whether existing licensed pharmacotherapies could reduce the spread of coronavirus disease 2019 (COVID-19). Methods: An open-label parallel randomized controlled trial was performed among healthy migrant workers quarantined in a large multi-storey dormitory in Singapore. Forty clusters (each defined [...]

Authors: Poenaru S, Abdallah SJ, Corrales-Medina V, Cowan J PMID: 33959278 PMCID: PMC8060761 DOI: 10.1177/20499361211009385 Abstract Coronavirus disease 2019 (COVID-19) is a viral infection which can cause a variety of respiratory, gastrointestinal, and vascular symptoms. The acute illness phase generally lasts no more than 2-3 weeks. However, there is increasing evidence that a proportion of [...]

Authors: Rossignol JF, Bardin MC, Oaks JB, Bostick BG, Vora KN. doi: https://doi.org/10.1101/2021.04.19.21255441 Abstract Background There is an urgent need for treatments to prevent the progression to severe COVID-19 and hospitalization. Methods This is a double-blind randomized multicenter study in 36 centers in the U.S. and Puerto Rico investigating the potential of a five-day treatment [...]

Authors: DiNicolantonio JJ, Barroso-Aranda J, McCarty MF PMID: 33875563 PMCID: PMC8057070 DOI: 10.1136/openhrt-2021-001655 Abstract Ivermectin, a drug commonly used to treat a range of parasitic infections, has been shown to halve the mortality elicited by a fatal dose of lipopolysaccharide in mice, in an oral dose (4 mg/kg) that can be extrapolated to 2–4 times the [...]

Authors: Wallukat G, Hohberger B, Wenzel K, Furst J, Wallukat A PMID: 33880442 PMCID: PMC8049853 DOI: 10.1016/j.jtauto.2021.100100 Abstract Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to the ones [...]

Authors: Shouman K, Vanichkachorn G, Chesire WP, Suarez MD, Shelly S PMID: 33860871 PMCID: PMC8050227 DOI: 10.1007/s10286-021-00803-8 Abstract Purpose: Post-COVID-19 syndrome is a poorly understood aspect of the current pandemic, with clinical features that overlap with symptoms of autonomic/small fiber dysfunction. An early systematic analysis of autonomic dysfunction following COVID-19 is lacking and may provide [...]

Authors: Wallukat G, Hohberger B, Wenzel K, Furst J, Wallukat A PMID: 33880442 PMCID: PMC8049853 DOI: 10.1016/j.jtauto.2021.100100 Abstract Impairment of health after overcoming the acute phase of COVID-19 is being observed more and more frequently. Here different symptoms of neurological and/or cardiological origin have been reported. With symptoms, which are very similar to the ones [...]

Authors: Porter C, Favara M, Scott D, Craske MG, Stein A PMID: 33858874 PMCID: PMC8053815 DOI: 10.1136/bmjopen-2021-049653 Abstract Objective: To provide evidence on the effect of the COVID-19 pandemic on the mental health of young people who grew up in poverty in low/middle-income countries (LMICs). Design: A phone survey administered between August and October 2020 [...]

Authors: Karimi A, Naeini F, Azar VA, Hasanzadeh M. PMID: 33940332 DOI: 10.1016/j.phymed.2021.153567 Abstract Background: Sepsis is a life-threatening condition caused by a dysregulated host response to infection. Several studies have indicated that flavonoids exhibit a wide variety of biological actions including free radical scavenging and antioxidant activities. Quercetin, one of the most extensively distributed [...]