Authors: Khazdair MR, Ghafari S, Sadeghi M. PMID: PMC8204995 doi: 10.1080/13880209.2021.1931353 Abstract Context COVID-19 is a novel coronavirus that causes a severe infection in the respiratory system. Nigella sativa L. (Ranunculaceae) is an annual flowering plant used traditionally as a natural food supplement and multipurpose medicinal agent. Objective The possible beneficial effects of N. sativa, [...]

Authors: Menendez-Arias L PMID: 34118236 PMCID: PMC8188802 DOI: 10.1016/j.jbc.2021.100867 Abstract Molnupiravir, a prodrug of the nucleoside derivative β-D-N4-hydroxycytidine (NHC), is currently in clinical trials for COVID-19 therapy. However, the biochemical mechanisms involved in molnupiravir-induced mutagenesis had not been explored. In a recent study, Gordon et al. demonstrated that NHC can be incorporated into viral RNA [...]

Authors: DiPierro F, Derosa G, Maffioli P, Togni S, Riva A PMID: 34135619 PMCID: PMC8197660 DOI: 10.2147/IJGM.S318720 Abstract Background: Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it [...]

Authors: Ohgitani E, Shin-Ya M, Ichitani M, Kobayashi M, Takihara T. PMID: 34201131 PMCID: PMC8227886 DOI: 10.3390/pathogens10060721 Abstract Saliva plays major roles in the human-to-human transmission of SARS-CoV-2. If the virus in saliva in SARS-CoV-2-infected individuals can be rapidly and efficiently inactivated by a beverage, the ingestion of the beverage may attenuate the spread of [...]

Quercetin, a well-known naturally occurring polyphenol, has recently been shown by molecular docking, in vitro and in vivo studies to be a possible anti-COVID-19 candidate. Quercetin has strong antioxidant, anti-inflammatory, immunomodulatory, and antiviral properties, and it is characterized by a very high safety profile, exerted in animals and in humans. Like most other polyphenols, quercetin shows a very low rate of oral absorption and its clinical use is considered by most of modest utility. Quercetin in a delivery-food grade system with sunflower phospholipids (Quercetin Phytosome®, QP) increases its oral absorption up to 20-fold.

Authors: Niaee MS, Gheibl N, Namdar P, Allami A, Javadi A. DOI: 10.4103/1995-7645.318304 Abstract Permissions ORIGINAL ARTICLE Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients A randomized multi-center clinical trial Niaee, Morteza Shakhsi1; Namdar, Peyman2; Allami, Abbas3; Zolghadr, Leila4; Javadi, Amir5; Karampour, Amin3; Varnaseri, Mehran6; Bijani, Behzad7; Cheraghi, Fatemeh1; Naderi, Yazdan8; Amini, Fatemeh9; [...]

Authors: Cuesta-Llavona E, Gomez J, Albaiceta GM, Amado-Rodriguez L, Garcia-Clemente M PMID: 34116286 PMCID: PMC8169316 DOI: 10.1016/j.intimp.2021.107825 Abstract The chemokine receptor CCR5 has been implicated in COVID-19. CCR5 and its ligands are overexpressed in patients. The pharmacological targeting of CCR5 would improve the COVID-19 severity. We sought to investigate the role of the CCR5-Δ32 variant [...]

Authors: Pont G, Pastorino L, Manfredini M, Ozben T, Oliva G, Kaleci S PMID: 34061414 PMCID: PMC8209953 DOI: 10.1002/jcla.23798 Abstract Background: Homocysteine assessment has been proposed as a potential predictive biomarker for the severity of COVID-19 infection. The purpose of this review was to analyze the correlation between the prevalence of MTHFR C677 T gene [...]

Auhtors: Mahatme MS, Bargade MB, Hiware SK, Motlag MM doi: https://doi.org/10.4103/jpp.jpp_8_21 Abstract Objectives: To compare the effects of atorvastatin and rosuvastatin in type II diabetes mellitus (T2DM) patients with dyslipidemia. Materialsand Methods: Eighty patients with history of T2DM of more than 3 months duration, glycated hemoglobin <7%, dyslipidemia, and normalelectrocardiogram were included in the randomized [...]

Authors: Jamme M, Mazeraud A PMID: 33769769 DOI: 10.1097/CCM.0000000000004926 Abstract We have read with a great interest the study by Fernandez et al (1) published in a recent issue of Critical Care Medicine. In this case-series, the authors reported the outcome of four patients admitted in ICU with coronavirus disease 2019 (COVID-19) complicated with multiorgan [...]