Auhtors: Rascio F, Spadaccino F, Rocchetti MT, Castellano G, Stallone G, Netti GS, Ranieri E PMID: 34439105 PMCID: PMC8394096 DOI: 10.3390/cancers13163949 Abstract The PI3K/AKT pathway is one of the most frequently over-activated intracellular pathways in several human cancers. This pathway, acting on different downstream target proteins, contributes to the carcinogenesis, proliferation, invasion, and metastasis of [...]

Authors: Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, et al. PMID: 34351721 PMCID: PMC8362594 DOI: 10.1056/NEJMoa2105911 Abstract Background: Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve [...]

Authors: Zhou S, Hill CS, Sarkar S, Tse LV, Woodburn BM PMID: 33961695 PMCID: PMC8136050 DOI: 10.1093/infdis/jiab247 Abstract Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral replication. β-d-N4-hydroxycytidine (NHC, initial metabolite of molnupiravir) is >100-fold more active [...]

Authors: Gupta AK, Venkataraman M, Talukder M, Bamimore MA PMID: 34291720 DOI: 10.1080/09546634.2021.1959506 Abstract Background and objectives: Finasteride 1 mg/day is indicated for androgen-dependent conditions such as male androgenetic alopecia (AGA). Methods: The literature is comprehensively summarized on the pharmacodynamics, pharmacokinetics, mechanism of action, and metabolism of finasteride. Pairwise and network meta-analyses were performed to [...]

Auhtors: Gorabi AM, Kiaie N, Aslani S, Sathyapalan T, Jamialahmadi T, Sahebkar A PMID: 34373771 PMCID: PMC8349293 DOI: 10.1155/2021/9599608 Abstract Statins, which are functionally known as 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) inhibitors, are lipid-lowering compounds widely prescribed in patients with cardiovascular diseases (CVD). Several biological and therapeutic functions have been attributed to statins, including neuroprotection, antioxidation, anti-inflammation, and [...]

Authors: Shu C, Feng S, Cui Q, Cheng S, Wang Y PMID: 34353036 DOI: 10.21037/apm-21-640 Abstract Background: Previous studies have reported that C reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) in Coronavirus disease 2019 (COVID-19) patients are significantly increased, and their progressive increases are clinical warning indicators of severe and critical severity. [...]

Authors: Tomassetti F, Nuccetelli M, Sarubbi S, Gisone F, Ciotti M PMID: 34339963 PMCID: PMC8313542 DOI: 10.1016/j.intimp.2021.108013 Abstract The antibody response to SARS-CoV-2 has not yet fully defined, but the availability of sensitive and specific serological assays is crucial to observe the presence of specific antibodies against the human receptor binding domain (S-RBD) and high [...]

Authors: Nejat R, Sadr AS, Freitas BT, Murray J, Pegan SD PMID: 34319871 DOI: 10.18433/jpps31931 Abstract Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent [...]

Authors: Hamed MG, Hagaga RS PMID: 32768893 PMCID: PMC7382922 DOI: 10.1016/j.mehy.2020.110140 Abstract While researchers are struggling to develop a vaccine for coronavirus disease, it is important to evolve effective therapeutic strategies to save lives. The majority of coronavirus disease deaths are due to pneumonia. Mostly, stress and depression are associated with coronavirus disease infection and [...]

Auhtors: Khandelwal A, Singh GP, Jamil S PMID: 34334890 PMCID: PMC8313054 DOI: 10.1016/j.mjafi.2021.06.002 No abstract available Keywords: Anti-viral; COVID-19; Ivermectin; SARS-CoV-2 Source: https://pubmed.ncbi.nlm.nih.gov/34334890/ Archive: https://archive.is/uArVB