Authors: Krause DN, Warfvinge K, Haanes KA, Edvinsson L PMID: 34545218 DOI: 10.1038/s41582-021-00544-2 Abstract Migraine is ranked as the second highest cause of disability worldwide and the first among women aged 15-49 years. Overall, the incidence of migraine is threefold higher among women than men, though the frequency and severity of attacks varies during puberty, [...]

Auhtors: Barclay AW, Augustin LS, Brighenti F, Delport E, Henry CJ, Sievenpiper JL, Yuexin Y PMID: 34579120 PMCID: PMC8466312 DOI: 10.3390/nu13093244 Abstract The glycaemic index (GI) is a food metric that ranks the acute impact of available (digestible) carbohydrates on blood glucose. At present, few countries regulate the inclusion of GI on food labels even [...]

Auhtors: Propovic KJ, Popvic DJ, Miljkovic D, Popvic JK, Lalosevic D, Posa M, Capo I PMID: 34536762 DOI: 10.1016/j.biopha.2021.112168 Abstract We investigated the anticancer effect of disulfiram and metformin combination on fibrosarcoma in hamsters. Hamsters of both sexes (~ 70 g) were randomly allocated to control and experimental groups (8 animals per group). In all [...]

Authors: Ader F, Hites M, Poissy J, Belhadi D, Diallo A, Staub T PMID: 34534511 PMCID: PMC8439621 DOI: 10.1016/S1473-3099(21)00485-0 Abstract Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital [...]

Authors: Malone B, Campbell EA PMID: 34518697 DOI: 10.1038/s41594-021-00657-8 Abstract Molnupiravir, a wide-spectrum antiviral that is currently in phase 2/3 clinical trials for the treatment of COVID-19, is proposed to inhibit viral replication by a mechanism known as ‘lethal mutagenesis’. Two recently published studies reveal the biochemical and structural bases of how molnupiravir disrupts the [...]

Authors: Draghici S, Nguyen TM, Sonna LA, Ziraldo C, Vanciu R, Fadel R et al. PMID: 33693506 PMCID: PMC7989618 DOI: 10.1093/bioinformatics/btab163 Abstract Motivation: COVID-19 has several distinct clinical phases: a viral replication phase, an inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is associated with patients developing cytokine storm syndrome. Treatment of [...]

Authors: Elamir YM, Amir H, Lim S, Rana Y, Lopez CG, Omar A PMID: 34508882 PMCID: PMC8425676 DOI: 10.1016/j.bone.2021.116175 Abstract The systemic illness associated with SARS-CoV-2 infection results in hospitalization rate of 380.3 hospitalizations per 100,000 population, overwhelming health care systems. Vitamin D regulates expression of approximately 11,000 genes spanning many physiologic functions that include [...]

Authors: Hurmach V, Platonov MO, Prylutska SV, Scharff P, Ritter U PMID: 34493768 PMCID: PMC8423725 DOI: 10.1038/s41598-021-97268-6 Abstract Based on WHO reports the new SARS-CoV-2 coronavirus is currently widespread all over the world. So far > 162 million cases have been confirmed, including > 3 million deaths. Because of the pandemic still spreading across the [...]

Authors:Michelen M, Manoharan L, Elkheir N, Cheng V, Dagens D, Hastie C. . PMID: PMC8478580 DOI: 10.1136/bmjgh-2021-005427 Abstract Background: While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, to help inform [...]

Authors: Hazan S, Stollman N, Bozkurt H, Dave S, Daniels J, Borody TJ. doi: https://doi.org/10.1101/2021.09.02.21262832 Abstract Objective To compare gut microbiome diversity and composition in SARS-CoV-2 polymerase chain reaction (PCR)-confirmed positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls. Design Using a cross-sectional study design, we used shotgun next-generation sequencing (NGS) [...]