Authors: Xin Y, Martin K, Morais CC, Gerard SE, Abate N, Sidhu U et al. PMID: 33938714 PMCID: PMC8448902 DOI: 10.1097/CCM.0000000000005071 Abstract Objectives: It is not known how lung injury progression during mechanical ventilation modifies pulmonary responses to prone positioning. We compared the effects of prone positioning on regional lung aeration in late versus early [...]

Authors: Reddy MP, Subramaniam A, Afroz A, Billah B, Lim ZJ, Wong SN PMID: 33927120 PMCID: PMC8439644 DOI: 10.1097/CCM.0000000000005086 Abstract Objectives: Several studies have reported prone positioning of nonintubated patients with coronavirus diseases 2019-related hypoxemic respiratory failure. This systematic review and meta-analysis evaluated the impact of prone positioning on oxygenation and clinical outcomes. Design and [...]

Authors: Kakavas S, Karayiannis D, Mastora Z PMID: 34684460 PMCID: PMC8537261 DOI: 10.3390/nu13103458 Abstract There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising [...]

Authors: Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS PMID: 34599878 PMCID: PMC8480964 DOI: 10.1016/S0140-6736(21)01960-7 Abstract Background: Over the course of the COVID-19 pandemic, the care of patients with COVID-19 has changed and the use of extracorporeal membrane oxygenation (ECMO) has increased. We aimed to examine patient selection, treatments, outcomes, and ECMO centre [...]

Authors: Nogues X, Overjero D, Pineda-Moncus M, Bouillon R PMID: 34097036 PMCID: PMC8344647 DOI: 10.1210/clinem/dgab405 Abstract Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims to elucidate the effect [...]

Authors: Marik P, Iglesias J, Varon J, Kory P PMID: 34569339 PMCID: PMC8477699 DOI: 10.1177/20587384211048026 Abstract COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. While enormous strides have been made in understanding the molecular pathways involved in patients [...]

Auhtors: Cheah KL, Norhayati MN, Husniati Yaacob L, Abdul Rahman R PMID: 34559859 PMCID: PMC8462692 DOI: 10.1371/journal.pone.0257843 Abstract Objective: To determine the effect of Ashwagandha extract on sleep. Methods: A comprehensive search was conducted in CENTRAL, MEDLINE, SCOPUS, Google Scholars, World Health Organization Trials Portal, ClinicalTrials.gov, Clinical Trial Registry of India, and AYUSH Research Portal [...]

Authors: Weinstock LB, Brook JB, Walters AS, Goris A, Afrin LB, Molderings GJ PMID: 34563706 PMCID: PMC8459548 DOI: 10.1016/j.ijid.2021.09.043 Abstract Objectives: Hyper-inflammation caused by COVID-19 may be mediated by mast cell activation (MCA) which has also been hypothesized to cause Long-COVID (LC) symptoms. We determined prevalence/severity of MCA symptoms in LC. Methods: Adults in LC-focused [...]

Auhtors: Astrup A, Teicholz N, Magkos F, Bier DM, Brenna JT, King JC, Mente A PMID: 34684304 PMCID: PMC8541481 DOI: 10.3390/nu13103305 Abstract The last decade has seen nearly 20 papers reviewing the totality of the data on saturated fats and cardiovascular outcomes, which, altogether, have demonstrated a lack of rigorous evidence to support continued recommendations [...]

Authors: Zuo T, Wu X, Wen W, Lan P PMID: 34560321 PMCID: PMC8478109 DOI: 10.1016/j.gpb.2021.09.004 Abstract Since the outset of the coronavirus disease 2019 (COVID-19) pandemic, the gut microbiome in COVID-19 has garnered substantial interest, given its significant roles in human health and pathophysiology. Accumulating evidence is unveiling that the gut microbiome is broadly altered [...]