Authors: Avendano-Sola C, Ramos-Martinez A, Munez-Rubio E, Ruiz-Antoran B, de Molina RM PMID: 34473652 PMCID: PMC8516461 DOI: 10.1172/JCI152740 Abstract BACKGROUND. Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19. Evidence from controlled clinical trials is inconclusive. METHODS. We conducted a randomized, open-label, controlled clinical trial at 27 hospitals in Spain. Patients had [...]

Authors:Borsche L, Glauner B, von Mendel J. PMID:PMC8541492 DOI: 10.3390/nu13103596 Abstract Background: Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further [...]

Authors: Peterson DJ. PMID: Abstract Keywords: Source: https://ago.nebraska.gov/sites/ago.nebraska.gov/files/docs/opinions/21-017_0.pdf Archive: https://archive.is/EoVhB

Authors: Hasan ZT, AlAtrakji MQ, Mehuaiden AK PMID: 34653660 PMCID: PMC8506572 DOI: 10.1016/j.ijid.2021.10.012 Abstract Objectives: This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19). Methods: This single-center, prospective, randomized clinical trial was conducted from 1 December 2020 to 1 June 2021 [...]

This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

Auhtors: Veglia F, Sanseviero E, Gabrilovich DI PMID: 34620838 PMCID: PMC8497485 DOI: 10.1038/s41392-021-00670-9 Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also promote tumor invasion via various non-immunological activities. Besides, this [...]

Auhtors: Azadi R, Mousavi SE, Kazemi NM, Yousefi-Manesh H, Rezayat SM, Jaafari MR PMID: 34600570 PMCID: PMC8487542 DOI: 10.1186/s40360-021-00525-7 Abstract Background: Berberine (BBR) is a plant alkaloid that possesses anti-inflammatory and anti-oxidant effects with low oral bioavailability. In this study, micelle formulation of BBR was investigated to improve therapeutic efficacy and examined its effect on [...]

Authors: Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, Chaves L PMID: 34599743 PMCID: PMC8487226 DOI: 10.1007/s11481-021-10015-6 Abstract Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-inflammation and neuronal damage result in a [...]

Auhtors: Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, Chaves L PMID: 34599743 PMCID: PMC8487226 DOI: 10.1007/s11481-021-10015-6 Abstract Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-inflammation and neuronal damage result in a [...]

Auhtors: Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, et al. PMID: 34591416 PMCID: PMC8958883 DOI: 10.20892/j.issn.2095-3941.2021.0306 Abstract The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development [...]