Auhtors: Zhang J-J, Wang D-W, Cai D, Lu Q, Cheng Y-X PMID: 34805099 PMCID: PMC8595597 DOI: 10.3389/fchem.2021.772740 Abstract Ganoderma fungi as popular raw materials of numerous functional foods have been extensively investigated. In this study, five pairs of meroterpenoid enantiomers beyond well-known triterpenoids and polysaccharides, dayaolingzhiols I-M (1-5), were characterized from Ganoderma lucidum. Their structures [...]

Authors: Holford P, Carr AC, Zawari M, Vizcaychipi MP PMID: 34833042 PMCID: PMC8624950 DOI: 10.3390/life11111166 Abstract Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin. Administration of intravenous vitamin C [...]

Authors: Oskotsky T, Maric I, Tang A, Oskotsky B, Wong RJ, Sirota M PMID: 34779847 PMCID: PMC8593759 DOI: 10.1001/jamanetworkopen.2021.33090 Abstract Importance: Antidepressant use may be associated with reduced levels of several proinflammatory cytokines suggested to be involved with the development of severe COVID-19. An association between the use of selective serotonin reuptake inhibitors (SSRIs)-specifically fluoxetine [...]

Severe respiratory infections are characterized by elevated inflammation and generation of reactive oxygen species (ROS) which may lead to a decrease in antioxidants such as vitamin C and a higher requirement for the vitamin.

Authors: Reis G, Moreira-Silva EA, Silva DC, Thabane L, Guyatt GH, Mills EJ PMID: 34717820 PMCID: PMC8550952 DOI: 10.1016/S2214-109X(21)00448-4 Abstract Background: Recent evidence indicates a potential therapeutic role of fluvoxamine for COVID-19. In the TOGETHER trial for acutely symptomatic patients with COVID-19, we aimed to assess the efficacy of fluvoxamine versus placebo in preventing hospitalisation [...]

Authors: Olajide O, Iwuanyanwu VU, Adegbola OD, Al-Hindawi AA PMID: 34709564 PMCID: PMC8551352 DOI: 10.1007/s12035-021-02593-6 Abstract In addition to respiratory complications produced by SARS‐CoV‐2, accumulating evidence suggests that some neurological symptoms are associated with the disease caused by this coronavirus. In this study, we investigated the effects of the SARS‐CoV‐2 spike protein S1 stimulation on [...]

Authors: Siegert A, Diedrich L, Antal A PMID: 34776903 PMCID: PMC8578968 DOI: 10.3389/fnhum.2021.730134 Abstract The world's population is aging. With this comes an increase in the prevalence of age-associated diseases, which amplifies the need for novel treatments to counteract cognitive decline in the elderly. One of the recently discussed non-pharmacological approaches is transcranial direct current [...]

Authors: Teselink J, Bawa KK, Koo GK, Sankhe K, Liu CS, Oh P PMID: 34700007 DOI: 10.1016/j.arr.2021.101499 Abstract Background: Non-invasive brain stimulation (NIBS) techniques have shown some promise in improving cognitive and neuropsychiatric symptoms (NPS) in people with Alzheimer's disease (AD) and its prodromal stage, mild cognitive impairment (MCI). However, data from clinical trials involving [...]

Authors:Ramiall V, Zucker J, Tatonetti N. PMID: PMC7574268 DOI: 10.1101/2020.10.15.20213546 Abstract Background Respiratory distress requiring intubation is the most serious complication associated with coronavirus disease 2019 (COVID-19). Methods In this retrospective study, we used survival analysis to determine whether or not mortality following intubation was associated with hormone exposure in patients treated at New York [...]

Authors: Tran HT, Gigl M, Le NP, Dawid C, Lamy E PMID: 34681279 PMCID: PMC8538008 DOI: 10.3390/ph14101055 Abstract To date, there have been rapidly spreading new SARS-CoV-2 "variants of concern". They all contain multiple mutations in the ACE2 receptor recognition site of the spike protein, compared to the original Wuhan sequence, which is of great [...]