By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%).

Characteristics and treatment of Omicron variant of COVID-19.

The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. Here, we report that the Omicron spike was resistant against most therapeutic antibodies but remained susceptible to inhibition by Sotrovimab.

Authors: Ospina-Tascon GA, Calderon-Tapia LE, Garcia AF, Zarama V, Vargas MP, Vaaron J PMID: 34874419 PMCID: PMC8652598 DOI: 10.1001/jama.2021.20714 Abstract Importance: The effect of high-flow oxygen therapy vs conventional oxygen therapy has not been established in the setting of severe COVID-19. Objective: To determine the effect of high-flow oxygen therapy through a nasal cannula compared [...]

Authors: Loucera C, Pena-Chilet M, Esteban-Medina M, Villegas R, Lopez-Miranda J PMID: 34862422 PMCID: PMC8642445 DOI: 10.1038/s41598-021-02701-5 Abstract COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival [...]

Authors: Miranda-Massari JR, Toro AP, Loh D, Rodriguez JR, Borges RM PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 Abstract Currently available anti-viral drugs may be useful in reducing the viral load but are not providing the necessary physiological effects to reduce the SARS-CoV-2 complications efficiently. Treatments that provide better clinical outcomes are urgently needed. Vitamin C [...]

Jorge R Miranda-Massari, Alondra P Toro, Doris Loh, Jose R Rodriguez, Raul Morales Borges, Victor Marcial-Vega, Jose Olalde, Miguel J Berdiel, Neil H Riordan, Juan Manuel Martinez, Armando Gil, Michael J Gonzalez PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 AbstractCurrently available anti-viral drugs may be useful in reducing the viral load but are not providing the [...]

Auhtors: Moding EJ, Nabet BY, Alizadeh AA, Diehn M PMID: 34785539 PMCID: PMC8976700 DOI: 10.1158/2159-8290.CD-21-0634 Abstract Growing evidence demonstrates that circulating tumor DNA (ctDNA) minimal residual disease (MRD) following treatment for solid tumors predicts relapse. These results suggest that ctDNA MRD could identify candidates for adjuvant therapy and measure response to such treatment. Importantly, factors [...]

Authors: Neil M, Fenton N, Smalley J, Craig C, Guetzkow J, Rose J DOI:10.13140/RG.2.2.14176.20483 Abstract The risk/benefit of Covid vaccines is arguably most accurately measured by an all-cause mortality rate comparison of vaccinated against unvaccinated, since it not only avoids most confounders relating to case definition but also fulfils the WHO/CDC definition of "vaccine effectiveness" [...]

Authors: Mohabatkar H, Behbahani M, Moradi M doi: https://doi.org/10.15414/jmbfs.4813 Abstract COVID-19 has shown higher virulence compared to the previous coronavirus epidemics and has shown that it causes damages to the nervous system. In the present study, PrionW web server was used to predict the prion-like domains (PrLDs) in 15 structural and nonstructural proteins of SARS-CoV, [...]