Authors: Morselli E, Galluzzi L, Kepp O, Criollo A, Maiuri MC, Madeo F PMID: 20157579 PMCID: PMC2815753 DOI: 10.18632/aging.100110 Abstract Although autophagy has widely been conceived as a self-destructive mechanism that causes cell death, accumulating evidence suggests that autophagy usually mediates cytoprotection, thereby avoiding the apoptotic or necrotic demise of stressed cells. Recent evidence produced [...]

Auhtors: Hursting SD, Smith SM, Lashinger LM, Harvey AE, Perkins SN PMID: 19969554 DOI: 10.1093/carcin/bgp280 Abstract Calorie restriction (CR) is arguably the most potent, broadly acting dietary regimen for suppressing the carcinogenesis process, and many of the key studies in this field have been published in Carcinogenesis. Translation of the knowledge gained from CR research [...]

Authors: Langguth B PMID: 19931642 DOI: 10.1016/j.drudis.2009.11.003 Abstract Tinnitus is the conscious perception of a phantom sound in the absence of an external source. For 1 in 100 of the general population, the condition severely affects quality of life. In spite of the fact that the market for a drug indicated for tinnitus relief is [...]

Auhtors: Godsland IF PMID: 19922415 PMCID: PMC2782313 DOI: 10.1042/CS20090399 Abstract Experimental, epidemiological and clinical evidence implicates insulin resistance and its accompanying hyperinsulinaemia in the development of cancer, but the relative importance of these disturbances in cancer remains unclear. There are, however, theoretical mechanisms by which hyperinsulinaemia could amplify such growth-promoting effects as insulin may have, [...]

Auhtors: Johnson JR, Burnell-Nugent M, Lossignol D, Ganae-Motan ED, Potts R, Fallon MT PMID: 19896326 DOI: 10.1016/j.jpainsymman.2009.06.008 Abstract This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced cancer. In total, 177 patients with cancer pain, [...]

Authors: Han M, Pendem S, Teh SL, Sukumaran DK, Wu F, Wilson JX PMID: 19840845 PMCID: PMC2818310 DOI: 10.1016/j.freeradbiomed.2009.10.034 Abstract Endothelial barrier dysfunction contributes to morbidity in sepsis. We tested the hypothesis that raising the intracellular ascorbate concentration protects the endothelial barrier from septic insult by inhibiting protein phosphatase type 2A. Monolayer cultures of microvascular [...]

Authors: Griffith RS, Norins AL, Kagan C PMID: 640102 DOI: 10.1159/000250926 Abstract Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312-1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from [...]

Auhtors: Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, Deberardinis RJ PMID: 19826036 PMCID: PMC2764330 DOI: 10.1158/0008-5472.CAN-09-2266 Abstract Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor [...]

Authors: Griffith RS, Wlash DE, Myrmel KH, Thompson RW PMID: 3115841 Abstract A double-blind, placebo-controlled, multicenter trial of oral L-lysine monohydrochloride for the prevention and treatment of recurrent herpes simplex (HSV) infection was conducted. The treatment group was given L-Lysine monohydrochloride tablets (1,000 mg L-lysine per dose) 3 times a day for 6 months. A [...]

Authors: Eisenberg T, Knauer H, Schauer A, Buttner S, Carmona-Gutierrez D, Ring J et al. PMID: 19801973 DOI: 10.1038/ncb1975 Abstract Ageing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of spermidine, a natural polyamine whose [...]