Authors: Renoir T PMID: 23596418 PMCID: PMC3627130 DOI: 10.3389/fphar.2013.00045 Abstract Besides demonstrated efficacy, selective serotonin reuptake inhibitors (SSRIs) hold other advantages over earlier antidepressants such as greater tolerability and a wider range of clinical applications. However, there is a growing body of clinical evidence which suggests that SSRIs could, in some cases, be associated with [...]

Authors: Fletcher RH doi:10.1001/jamainternmed.2013.2305 Abstract Vitamin deficiency diseases, such as pellagra, rickets, beriberi, night blindness, and scurvy, used to account for an enormous burden of suffering worldwide. One by one, the underlying dietary deficiencies were defined, and, in the early part of the 20th century, the chemical structures of the missing nutrients were identified. While [...]

Authors: Nowotarski SL, Woster PM, Casero RA PMID: 23432971 PMCID: PMC4027058 DOI: 10.1017/erm.2013.3 Abstract Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport system. [...]

Auhtors: Daniels K, Mosher WD PMID: 24988816 Abstract Objective: This report presents national estimates of the proportion of sexually experienced women aged 15-44 who have ever used various methods of contraception in the United States. Trends are shown since 1982, and results are shown by Hispanic origin and race, education, and religious affiliation. The number [...]

Authors: Lee MR, Wehring HJ, McMahon RP, Cascella N, Liu F, Bellack A et al. PMID: 23415472 PMCID: PMC4125132 DOI: 10.1016/j.schres.2013.01.001 Abstract Background: Deficits in olfactory identification have been widely reported in patients with schizophrenia (SZ) and are associated with negative symptomatology. Adjunctive oxytocin delivered intranasally has been shown to improve some aspects of social [...]

Auhtors: Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y, Hiraoka N PMID: 23385730 PMCID: PMC3590668 DOI: 10.1038/bjc.2013.32 Abstract Background: The host immune reaction is represented by immune/inflammatory cell infiltrates. Here we systematically analysed tumour-infiltrating immune/inflammatory cells in pancreatic ductal carcinoma (PDC) and evaluated their clinicopathological impact. Methods: Using immunohistochemistry, we examined [...]

Auhtors: Ramsden CE, Zamora D, Faurot KR, Ringel A, Davis JM, Hibbeln JR PMID: 23386268 PMCID: PMC4688426 DOI: 10.1136/bmj.e8707 Abstract Objective: To evaluate the effectiveness of replacing dietary saturated fat with omega 6 linoleic acid, for the secondary prevention of coronary heart disease and death. Design: Evaluation of recovered data from the Sydney Diet Heart [...]

Authors: Usami O, Saitoh H, Ashino Y, Hattori T PMID: 23337623 DOI: 10.1620/tjem.229.137 Abstract Acyclovir is known for its antiviral activity against some pathogenic viruses such as the Epstein-Barr virus (EBV) that causes infectious mononucleosis (IM) and IM-like illness. Therefore, we empirically administered acyclovir to patients with suspected EBV-IM and IM like-illness, upon their admission [...]

Auhtors: Shimazu T, Hirschey MD, Newman J, He W, Shirakawa K, Le Moan N, et al. PMID: 23223453 PMCID: PMC3735349 DOI: 10.1126/science.1227166 Abstract Concentrations of acetyl-coenzyme A and nicotinamide adenine dinucleotide (NAD(+)) affect histone acetylation and thereby couple cellular metabolic status and transcriptional regulation. We report that the ketone body d-β-hydroxybutyrate (βOHB) is an endogenous [...]

Auhtors: Seyfried TN, Huysentruyt LC PMID: 23237552 PMCID: PMC3597235 DOI: 10.1615/critrevoncog.v18.i1-2.40 Abstract Metastasis involves the spread of cancer cells from the primary tumor to surrounding tissues and to distant organs and is the primary cause of cancer morbidity and mortality. In order to complete the metastatic cascade, cancer cells must detach from the primary tumor, [...]