Auhtors: Li Z, Geng YN, Jiang JD, Kong WJ PMID: 24669227 PMCID: PMC3942282 DOI: 10.1155/2014/289264 Abstract Oxidative stress and inflammation are proved to be critical for the pathogenesis of diabetes mellitus. Berberine (BBR) is a natural compound isolated from plants such as Coptis chinensis and Hydrastis canadensis and with multiple pharmacological activities. Recent studies showed [...]

Authors: Ishima T, Fujita Y, Hashimoto K PMID: 24508523 DOI: 10.1016/j.ejphar.2014.01.064 Abstract The sigma-1 receptor chaperone located in the endoplasmic reticulum (ER) may be implicated in the mechanistic action of some antidepressants. The present study was undertaken to examine whether new antidepressant drugs interact with the sigma-1 receptor chaperone. First, we examined the effects of [...]

Auhtors: Giraldo NA, Becht E, Remark R, Damotte D, Sautès-Fridman C, Fridman WH PMID: 24487185 DOI: 10.1016/j.coi.2014.01.001 Abstract A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates [...]

Authors: Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT PMID: 24466319 PMCID: PMC3900701 DOI: 10.1371/journal.pone.0087026 Abstract There is considerable interest in defining new agents or targets for antithrombotic purposes. The 5-HT2A receptor is a G-protein coupled receptor (GPCR) expressed on many cell types, and a known therapeutic target for many disease states. This [...]

Authors: Giuliani C, Bucci I, Di Santo S, Rossi C, Grassadonia A, Piantelli M. PMID: 24447974 DOI: 10.1016/j.fct.2014.01.016 Abstract Quercetin is the most abundant flavonoid present in a broad range of fruit and vegetables. Furthermore, quercetin is available as dietary supplements that are based on its antioxidant, antiproliferative and anti-inflammatory properties. However, concerns have been [...]

Authors: Colombo D, Lunardon L, Bellia G. PMID: 24527031 doi: 10.1155/2014/145325 Abstract Cyclosporine (CyA) is a well-known immunosuppressant with a narrow therapeutic window. Its bioavailability is affected by many other traditional drugs and herbal extracts. Cytochrome P-450 isoenzymes CYP3A4 and CYP3A5 and protein P-glycoprotein (P-gp) are involved in CyA bioavailability. Interactions of CyA with herbal [...]

Auhtors: Seyfried TN, Shelton LM PMID: 24343361 PMCID: PMC3941741 DOI: 10.1093/carcin/bgt480 Abstract Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The genomic instability observed in tumor cells and all other recognized hallmarks of cancer are considered downstream epiphenomena of the initial disturbance of cellular [...]

Auhtors: Komohara Y, Jinushi M, Takeya M PMID: 24168081 PMCID: PMC4317877 DOI: 10.1111/cas.12314 Abstract The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept of macrophage differentiation into a classically activated phenotype (M1) and an alternatively activated phenotype (M2), [...]

Auhtors: Zhang D-W, Fu M, Gao S-H, Liu J-L PMID: 24348712 PMCID: PMC3857752 DOI: 10.1155/2013/636053 Abstract Turmeric (Curcuma longa), a rhizomatous herbaceous perennial plant of the ginger family, has been used for the treatment of diabetes in Ayurvedic and traditional Chinese medicine. The active component of turmeric, curcumin, has caught attention as a potential treatment [...]

Auhtors: Gandini S, De Vries E, Tosti G, Botteri E, Spadola G, Maisonneuve P, et al. PMID: 24223851 PMCID: PMC3817085 DOI: 10.1371/journal.pone.0078820 Abstract Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma [...]