Authors: Mallat J, Lemyze M, Thevenin D PMID: 27293820 PMCID: PMC4885988 DOI: 10.21037/jtd.2016.04.32 Abstract Thiamine was the first B vitamin to be identified and is also referred to as vitamin B1. It is a water-soluble vitamin that is an indispensable constituent of cellular metabolism. A lack of this vitamin can, therefore, be potentially life-threatening. Thiamine [...]

Authors: van Zuuren EJ, Fedorowicz Z, Schoones J PMID: 27225981 PMCID: PMC6457957 DOI: 10.1002/14651858.CD007628.pub4 Abstract Background: Female pattern hair loss (FPHL), or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and [...]

Auhtors: Nassar D, Blanpain C PMID: 27193450 DOI: 10.1146/annurev-pathol-012615-044438 Abstract Different mechanisms contribute to intratumor heterogeneity, including genetic mutations, the microenvironment, and the existence of subpopulations of cancer cells with increased renewal capacity and the ability to recapitulate the heterogeneity found in primary tumors, which are referred to as cancer stem cells (CSCs). In this [...]

Auhtors: Creed SA Abstract We've been told for years that eating fat is bad for us, that it is a primary cause of high blood pressure, heart disease and obesity. The Real Meal Revolution debunks this lie and shows us the way back to restored health through eating what human beings are meant to eat. [...]

Auhtors: Keadle SK, McKinnon R, Graubard BI, Troiano RP PMID: 27196146 PMCID: PMC4969157 DOI: 10.1016/j.ypmed.2016.05.009 Abstract This paper examined how many older adults (65+years) are meeting physical activity (PA) Guidelines (PAG; 150min/week of moderate-to-vigorous PA) using data from three leading national surveys (NHANES, BRFSS and NHIS). The proportion of individuals meeting aerobic PAG was determined [...]

Authors: Karatas F, Sahin S, sever AR, Altundag K PMID: 27247882 PMCID: PMC4864803 DOI: 10.1186/s40064-016-2216-3 Abstract Endocrine therapy-induced hair loss (ETIHL) associated with aromatase inhibitors and tamoxifen treatment is currently mostly reported but remained an unresolved therapeutic issue in patients with breast cancer (BC) since the number of studies regarding the management is limited in [...]

Authors: Meduri GU, Bridges L, Shih MC, Marik PE, Siemienluk RA, Kocak M PMID: 26508525 Abstract PURPOSE: To investigate the effect of prolonged glucocorticoid treatment for patients with acute respiratory distress syndrome (ARDS). METHODS: We conducted two sets of intention-to-treat analyses: (1) a primary analysis of individual patients' data (IPD) of four randomized controlled trials [...]

Authors: Rossignol JF PMID: 27095301 PMCID: PMC7102735 DOI: 10.1016/j.jiph.2016.04.001 Abstract Nitazoxanide is a broad-spectrum antiviral agent undergoing clinical development for treatment of influenza and other viral respiratory infections. Nitazoxanide exhibits in vitro activity against Middle East respiratory syndrome coronavirus (MERS-CoV) and other coronaviruses, inhibiting expression of the viral N protein. Nitazoxanide also suppresses production of [...]

Authors: Seale LR, Eglini AN, McMichael AJ PMID: 27050696 Abstract 5 α-reductase inhibitors such as finasteride and dutasteride have been studied for the treatment of hair loss in men, with finasteride being the only Food and Drug Administration-approved treatment. Increasingly, in recent years, off-label use of these drugs has been employed in the treatment of [...]

Auhtors: Ramsden CE, Zamora D, Faurot KR, Broste SK, Frantz RP, Davis JM, Ringel A PMID: 27071971 PMCID: PMC4836695 DOI: 10.1136/bmj.i1246 Abstract Objective: To examine the traditional diet-heart hypothesis through recovery and analysis of previously unpublished data from the Minnesota Coronary Experiment (MCE) and to put findings in the context of existing diet-heart randomized controlled [...]