Authors: Tan CW, Ho LP, Kalimuddin S, Cherng BP, Teh YE PMID: 33039952 PMCID: PMC7832811 DOI: 10.1016/j.nut.2020.111017 Abstract Objectives: The aim of this study was to determine clinical outcomes of older patients with coronavirus (COVID-19) who received a combination of vitamin D, magnesium, and vitamin B12 (DMB) compared with those who did not. We hypothesized [...]

Auhtors: Heiskanen V, Pfiffner M, Partonen T doi: https://doi.org/10.1016/j.arr.2020.101089 Abstract Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast [...]

New research provides evidence of an impaired vitamin D gene signature in CD4+ T cells in patients with severe COVID-19. Mechanistically, it is shown that vitamin D alters the epigenetic landscape of CD4+ T cells, as well as inducing key transcription factors such as STAT3, BACH2 and JUN that reduce levels of IFN-γ and increase IL-10. These changes generate pro-resolving TH1 cells that may be beneficial in resolving or preventing severe COVID-19.

Authors: Henriquez MS, de Tejada Romero MJ PMID: 32486496 PMCID: PMC7352679 doi: 10.3390/nu12061617 Abstract Vitamin D deficiency is a global health problem due to its high prevalence and its negative consequences on musculoskeletal and extra-skeletal health. In our comparative review of the two exogenous vitamin D supplementation options most used in our care setting, we [...]

To investigate the association between serum 25-hydroxyvitamin D levels and its effect on adverse clinical outcomes, and parameters of immune function and mortality due to a SARS-CoV-2 infection.

Auhtors: Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. PMID: 30415629 PMCID: PMC6425757 DOI: 10.1056/NEJMoa1809944 Abstract Background: It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods: We conducted a nationwide, randomized, placebo-controlled trial, with [...]

Auhtors: Reddy P, Edwards LR PMID: 28471760 DOI: 10.1097/MJT.0000000000000538 Abstract Background: Vitamin D and magnesium (Mg) are some of the most studied topics in medicine with enormous implications for human health and disease. Majority of the adults are deficient in both vitamin D and magnesium but continue to go unrecognized by many health care professionals. [...]

Auhtors: Ng K, Venook AP, Sato K, Yuan C, Hollis BW, Chang IW, et al. doi: https://doi.org/10.1200/jco.2015.33.15_suppl.3503 Abstract Background: Prospective epidemiologic data suggest that higher levels of 25-hydroxyvitamin D [25(OH)D] are associated with improved survival in patients with colorectal cancer, however the relationship between 25(OH)D and outcome in metastatic CRC (mCRC), specifically, is unknown. Methods: [...]

Auhtors: Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, et al. PMID: 24690623 PMCID: PMC3972416 DOI: 10.1136/bmj.g1903 Abstract Objective: To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. Design: Systematic review and meta-analysis of [...]

The aim of the present study is to summarize existing literature on vitamin D levels in adults in different continents and different countries worldwide. The best determinant of vitamin D status is the serum concentration of 25-hydroxyvitamin D (25(OH)D).