Authors: Colunga Biancatelli RM, Berrill M, Marik PE PMID: 31852327 DOI: 10.1080/14787210.2020.1706483 Abstract There is a growing interest in the administration of vitamin C beyond the treatment of hypovitaminosis C in malnourished patients. This has been driven by a 2016 ‘before-after’ study which suggested a substantial survival benefit from a protocol that included hydrocortisone, ascorbic [...]

Authors: Howell AP, Parrett JL, Malcom DR PMID: 31766883 PMCID: PMC8256056 DOI: 10.1177/1932296819889638 Abstract Background: Intravenous vitamin C therapy has been associated with reduced mortality in patients with sepsis. Of potential concern with this therapy are falsely elevated point-of-care (POC) blood glucose values vs laboratory analyzed (LA) readings. The purpose of this study was to [...]

Authors: Fowler AA, Truwit JD, Hite D, Morris PE, DeWilde C, Priday A et al. PMID: 31573637 PMCID: PMC6777268 DOI: 10.1001/jama.2019.11825 Abstract Importance: Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis and acute respiratory distress syndrome (ARDS). Objective: To determine the effect of intravenous vitamin C infusion [...]

Authors: Stephenson E, Hooper MH, Marik PE DOI:https://doi.org/10.1016/j.chest.2018.08.232 Abstract PURPOSE: The use of intravenous vitamin C for sepsis is increasing. Vitamin C interferes with point-of-care (POC) glucose monitoring devices that use the glucose-dehydrogenase method of testing (e.g. Accu-Chek, Roche, Indianapolis, IN). Spuriously elevated POC glucose levels have been reported in patients with burns after large [...]

Authors: Marik PE PMID: 29684467 DOI: 10.1016/j.pharmthera.2018.04.007 Abstract Most vertebrates can synthesize vitamin C with synthesis increasing during stress. Humans, however, have lost the ability to synthesize vitamin C. Vitamin C is an important anti-oxidant and an enzyme cofactor for many important biological reactions. Sepsis results in the overwhelming production of reactive oxygen species with [...]

Authors: Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J PMID: 27940189 DOI: 10.1016/j.chest.2016.11.036 Abstract Background: The global burden of sepsis is estimated as 15 to 19 million cases annually, with a mortality rate approaching 60% in low-income countries. Methods: In this retrospective before-after clinical study, we compared the outcome and clinical course of [...]

Authors: Al-Jassim KB, Jawad AA, Al-Masoudi EA, Majeed SK Abstract The objective of this study was to assess the effects of repeated administration of ivermectin alone or with the combination of Vitamin C on kidney function and histopathological effects on kidney and lung of rabbits. Total of 48 mature female rabbits were used in this [...]

Authors: McHugh GJ, Graber ML, Freebairn RC PMID: 18714631 DOI: 10.1177/0310057X0803600413 Abstract Although daily ingestion of high-dose vitamin C is generally regarded as largely innocuous, fatal nephrotoxicity can occur in some rare circumstances. We report a case where the patient, who chose to forgo any advanced conventional medical intervention (dialysis and mechanical ventilation), had failed [...]

Authors: Mashour S, Turner JF, Merrell R PMID: 10936161 DOI: 10.1378/chest.118.2.561 Abstract With the increased use of nonprescription vitamin supplementation, physicians involved in critical care must be aware of the potential complications of these medications. We report the case of a 31-year-old African-American man presenting to the emergency department with acute renal failure. He had [...]

Authors: Auer BL PMID: 9767367 DOI: 10.1046/j.1365-2362.1998.00349.x Abstract Background: Long-term or high-dosage consumption of vitamin C may play a role in calcium oxalate kidney stone formation. The present study was undertaken to determine the biochemical and physicochemical risk factors in a male subject who developed haematuria and calcium oxalate crystalluria after ingestion of large doses [...]