Auhtors: Zhao X, Qu J, Sun Y, Wang J, Liu x, Wang F, et al. PMID: 28427165 PMCID: PMC5444766 DOI: 10.18632/oncotarget.15736 Abstract Purpose: Tumor associated macrophages (TAMs) are important prognostic factors and have been proved to be associated with the invasion and migration of various cancer. However, the relationship between TAMs and breast cancer outcomes [...]

Auhtors: Nowell CS, Radtke F PMID: 28154375 DOI: 10.1038/nrc.2016.145 Abstract The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role in regulating development and homeostasis in various tissues. The cellular processes and events that it controls are diverse, and continued investigation over recent decades has revealed how the role of Notch [...]

Auhtors: Williamson T, Bai RY, Staedtke V, Huso D, Riggins GJ PMID: 27612418 PMCID: PMC5356574 DOI: 10.18632/oncotarget.11851 Abstract Inheritance of a gene mutation leads to the initiation of 5 to 10% of most cancers, including colon cancer cases. We developed a chemoprevention strategy using a novel combination of the non-steroidal anti-inflammatory (NSAID) sulindac plus the [...]

Auhtors: Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. PMID: 27381735 PMCID: PMC4935811 DOI: 10.1038/ncomms12150 Abstract Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both [...]

Auhtors: Savage P PMID: 25605631 PMCID: PMC4308945 DOI: 10.1186/s12885-015-1006-6 Abstract Background: A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical [...]

Auhtors: Beury DW, Parker KH, Nyandjo M, Sinha P, Carter KA, Ostrand-Rosenberg S PMID: 25170116 PMCID: PMC4226789 DOI: 10.1189/jlb.3A0414-210R Abstract MDSC and macrophages are present in most solid tumors and are important drivers of immune suppression and inflammation. It is established that cross-talk between MDSC and macrophages impacts anti-tumor immunity; however, interactions between tumor cells [...]

Auhtors: Giraldo NA, Becht E, Remark R, Damotte D, Sautès-Fridman C, Fridman WH PMID: 24487185 DOI: 10.1016/j.coi.2014.01.001 Abstract A tumour grows in a complex microenvironment composed of stromal cells, lymphoid and myeloid cells, vascular and lymphatic vessels, and the resultant cytokine and chemokine milieu. In most primary tumours, a strong Th1/cytotoxic T cells infiltration correlates [...]

Auhtors: Komohara Y, Jinushi M, Takeya M PMID: 24168081 PMCID: PMC4317877 DOI: 10.1111/cas.12314 Abstract The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known. With the recent introduction of the novel concept of macrophage differentiation into a classically activated phenotype (M1) and an alternatively activated phenotype (M2), [...]

Auhtors: Fridman WH, Pagès F, Sautès-Fridman C, Galon J PMID: 22419253 DOI: 10.1038/nrc3245 Abstract Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this [...]

Auhtors: Lee C, Raffaghello L, Brandhorst S, Safdie FM, Bianchi G, Pistoria V, Wei M. PMID: 22323820 PMCID: PMC3608686 DOI: 10.1126/scitranslmed.3003293 Abstract Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment with starvation conditions sensitized yeast cells [...]