Auhtors: Heng Y, Zhu X, Lin H, Jingyu M, Ding X, Tao L, Lu L PMID: 36864443 PMCID: PMC9983170 DOI: 10.1186/s12967-023-03910-4 Abstract Background: Tumor-associated macrophages (TAMs) are major component in the tumor microenvironment (TME) and play regulatory role in tumor progression. We aimed to investigate the infiltration and prognostic value of TAMs in laryngeal squamous [...]

Auhtors: Wang Q, Shao X, Zhang Y, Zhu M, Wang FXC, Mu J, et al. PMID: 36807772 PMCID: PMC10242329 DOI: 10.1002/cam4.5698 Abstract Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in [...]

Auhtors: Cole K, Al-Kadhimi Z, Talmadge JE PMID: 36640224 PMCID: PMC9840433 DOI: 10.1007/s10555-023-10079-1 Abstract The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality and is a crucial therapeutic target in oncology. Thus, it is critical to establish a better understanding of metastatic progression for the future [...]

Auhtors: Kumari N, Choi SH PMID: 35183252 PMCID: PMC8857848 DOI: 10.1186/s13046-022-02272-x Abstract Cancer immunotherapy has emerged as a novel cancer treatment, although recent immunotherapy trials have produced suboptimal outcomes, with durable responses seen only in a small number of patients. The tumor microenvironment (TME) has been shown to be responsible for tumor immune escape and [...]

Auhtors: Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, et al. PMID: 35053426 PMCID: PMC8774531 DOI: 10.3390/cells11020310 Abstract Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of [...]

Auhtors: Ma T, Renz BW, Ilmer M, Koch D, Yang Y, Werner J, Bazhin AV PMID: 35053426 PMCID: PMC8774531 DOI: 10.3390/cells11020310 Abstract Myeloid-derived suppressor cells (MDSCs) are one of the main suppressive cell population of the immune system. They play a pivotal role in the establishment of the tumor microenvironment (TME). In the context of [...]

Auhtors: Komohara Y, Niino D, Ohnishi K, Ohshima K, Takeya M PMID: 34298810 PMCID: PMC8304632 DOI: 10.3390/cancers13143597 Abstract The tumor microenvironment includes dendritic cells, T-cytotoxic, T-helper, reactive B-lymphoid cells and macrophages; these reactive cells could interplay with malignant cells and promote tumor growth and survival. Among its cellular components, tumor-associated macrophages (TAM) represent a component [...]

Auhtors: Pan Y, Yu Y, Wang X, Zhang T PMID: 33365025 PMCID: PMC7751482 DOI: 10.3389/fimmu.2020.583084 Abstract Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated M2 macrophages. The former typically exerts anti-tumor functions, [...]

Auhtors: Li C, Jiang P, Wei S, Xu X, Wang J PMID: 32680511 PMCID: PMC7367382 DOI: 10.1186/s12943-020-01234-1 Abstract Regulatory T cells (Tregs) characterized by the expression of the master transcription factor forkhead box protein p3 (Foxp3) suppress anticancer immunity, thereby hindering protective immunosurveillance of tumours and hampering effective antitumour immune responses in tumour-bearing hosts, constitute [...]

Auhtors: Yan HH, Pickup M, Pang Y, Gorska AE, Li Z, Chytil A, et al. PMID: 20631080 PMCID: PMC4675145 DOI: 10.1158/0008-5472.CAN-10-0706 Abstract The mechanisms by which a primary tumor affects a selected distant organ before tumor cell arrival remain to be elucidated. This report shows that Gr-1+CD11b+ cells are significantly increased in lungs of mice [...]