Authors: Jalali F, Rezaie S, Rola P, Kyle-Sidell C doi: http://dx.doi.org/10.2139/ssrn.3800402 Abstract Established evidence suggests that in ARDS, platelets may exhibit a dysregulated state that exacerbates lung injury. We review evidence that suggests this platelet-mediated lung injury, while present in ARDS in general, is amplified in COVID-19 ARDS in particular. Driven by a quantifiably higher [...]

Authors: Lau T, Horschitz S, Berger S, Bartsch D, Schloss P PMID: 18216289 DOI: 10.1096/fj.07-095471 Abstract A deficiency of serotonergic signaling is thought to be involved in the etiology of depression. Thus, drugs blocking the reuptake of serotonin back into the neurons are widely used in treatment of this disease; however, their delayed effect in [...]

Authors: Blackshear JL, Orlandi C, Hollenberg NK PMID: 1708058 DOI: 10.1097/00005344-199101000-00010 Abstract Serotonin (5HT) has been implicated in the pathogenesis of several arterial disorders. Experimental intrarenal infusion of 5HT has produced initial decreases, and later sustained increases in total renal blood flow in the dog, and flow limiting renal artery spasm in other species. We [...]

Authors: Dawson C, Christensen CW, Rickaby DA, Linehan JH, Johnston MR PMID: 2409068 DOI: 10.1152/jappl.1985.58.6.1761 Abstract We examined the influence of glass bead embolization and oleic acid, dextran, and imipramine infusion on the pulmonary uptake of trace doses of [3H]serotonin and the extravascular volume accessible to [14C]antipyrine in anesthetized dogs. Embolization and imipramine decreased serotonin [...]