Authors: Sharun K, Dhama K, Patel SK, Pathak M, Tiwari R PMID: 32473642 PMCID: PMC7261036 DOI: 10.1186/s12941-020-00368-w Abstract The recent report by Caly et al., describing the antiviral potential of ivermectin against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro arrive to the agenda of potential candidates for COVID-19 treatment. This discovery gave [...]

Authors: Cruz AF, Ruiz-Antoran B, Gomez AM, Lopez AS doi: https://doi.org/10.1101/2020.05.22.20110544 Abstract Objective We aim to determine the impact of steroid use in COVID-19 pneumonia in-hospital mortality. Design We performed a single-centre retrospective cohort study. Setting A University hospital in Madrid, Spain, during March 2020. Participants Patients admitted with SARS-CoV-2 pneumonia. Exposures Patients treated with [...]

Authors: Tripathy S, Dassarma B, Roy S, Chabalala H, Matsabisa MG PMID: 32450198 PMCID: PMC7243790 DOI: 10.1016/j.ijantimicag.2020.106028 Abstract Chloroquine (CQ) and its analogue hydroxychloroquine (HCQ) have long been used worldwide as frontline drugs for the treatment and prophylaxis of human malaria. Since the first reported cases in Wuhan, China, in late December 2019, humans have [...]

Authors: Bryce C, Grimes Z, Pujadas E, Ahuja S, Beasley MB, Albrecht R et al. PMID: 33795830 PMCID: PMC8015313 DOI: 10.1038/s41379-021-00793-y Abstract BACKGROUND Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe, disproportionately affecting New York City. A comprehensive, integrative autopsy series that [...]

Authors: Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S PMID: 32416070 PMCID: PMC7227586 DOI: 10.1016/j.cell.2020.04.026 Abstract Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an [...]

The coronavirus, COVID-19, has infected hundreds of thousands and killed tens of thousands of individuals worldwide. This highly infectious condition continues to ravage the world population and has yet to reach it peak infective rate in some countries.

Authors: Kurcicka L, Lauer SA, Laeyendecker O, Boon D, Lessler J PMID: 32422057 PMCID: PMC7240870 DOI: 10.7326/M20-1495 Abstract Background: Tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) based on reverse transcriptase polymerase chain reaction (RT-PCR) are being used to rule out infection among high-risk persons, such as exposed inpatients and health care workers. It [...]

Authors: Spinelli FR, Conti F, Gadina M PMID: 32385052 DOI: 10.1126/sciimmunol.abc5367 Abstract JAK kinase inhibitors are being investigated as a way of managing cytokine storm in severe COVID-19 patients. Keywords: SARS-CoV-2, JAK inhibitors, COVID-19 Source: https://pubmed.ncbi.nlm.nih.gov/32385052/ Archive: https://archive.ph/Jwcrd

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks.

Authors: Li MY, Li L, Zhang Y, Wang XS PMID: 32345362 PMCID: PMC7186534 DOI: 10.1186/s40249-020-00662-x Abstract Background: Since its discovery in December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 2 180 000 people worldwide and has caused more than 150 000 deaths as of April 16, 2020. SARS-CoV-2, which is [...]