Authors: Westendorf K, Zentelis S, Wang L, Foster D, Wiggin M, Lovett E PMID: 33972947 PMCID: PMC8109210 DOI: 10.1101/2021.04.30.442182 Abstract NIH NLM LogoLog in Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation pubmed logo Search: Search Advanced User Guide SaveEmailSend to Display options full text links full text provider logo actions Cite Collections share page navigation Preprint [...]

Authors: Roltgen K, Nielsen SC, Silva O, Younes SF, Yang F, Wirz OF PMID: 35148837 PMCID: PMC8786601 DOI: 10.1016/j.cell.2022.01.018 Abstract During the SARS-CoV-2 pandemic, novel and traditional vaccine strategies have been deployed globally. We investigated whether antibodies stimulated by mRNA vaccination (BNT162b2), including third-dose boosting, differ from those generated by infection or adenoviral (ChAdOx1-S and [...]

Authors: Jeffreys L, Pennington SH, Duggan J, Breen A, Jinks J PMID: 35093538 PMCID: PMC8801767 DOI: 10.1016/j.ijantimicag.2022.106542 Abstract A key element for the prevention and management of coronavirus disease 2019 is the development of effective therapeutics. Drug combination strategies offer several advantages over monotherapies. They have the potential to achieve greater efficacy, to increase the [...]

Auhtors: Pliss A, Kuzmin AN, Prasad PN, Mahajan SD PMID: 35049274 PMCID: PMC8790819 DOI: 10.1021/acschemneuro.1c00675 Abstract The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to mitochondrial dysfunction of brain microglia cells. However, the changes in biochemical content of mitochondria that drive the progression [...]

The SARS-CoV-2 B.1.1.529 (Omicron) variant contains 15 mutations of the receptor-binding domain (RBD). How Omicron evades RBD-targeted neutralizing antibodies requires immediate investigation.

Authors: Molina-Carballo A, Palacios-Lopez R, Jerez-Calero A, Agil A PMID: 35723382 PMCID: PMC8929125 DOI: 10.3390/cimb44010003 Abstract according to the World Health Organization (WHO), COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, responsible for an increasing number of cases and deaths. From a preventive and therapeutic point of view, there are two concerns that [...]

By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most cases were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous SARS-CoV-2 infection. The majority of cases with available information reported symptoms (509/666; 76%) and most were infected in Denmark (588/644; 91%).

Characteristics and treatment of Omicron variant of COVID-19.

Jorge R Miranda-Massari, Alondra P Toro, Doris Loh, Jose R Rodriguez, Raul Morales Borges, Victor Marcial-Vega, Jose Olalde, Miguel J Berdiel, Neil H Riordan, Juan Manuel Martinez, Armando Gil, Michael J Gonzalez PMID: 34947872 PMCID: PMC8708699 DOI: 10.3390/life11121341 AbstractCurrently available anti-viral drugs may be useful in reducing the viral load but are not providing the [...]

Authors: Mohabatkar H, Behbahani M, Moradi M doi: https://doi.org/10.15414/jmbfs.4813 Abstract COVID-19 has shown higher virulence compared to the previous coronavirus epidemics and has shown that it causes damages to the nervous system. In the present study, PrionW web server was used to predict the prion-like domains (PrLDs) in 15 structural and nonstructural proteins of SARS-CoV, [...]