Auhtors: Diaz-Resendiz KJ, Benitez-Trinidad AB, Covantes-Rosales CE, Toledo-Ibarra GA PMID: 35355308 PMCID: PMC9088601 DOI: 10.1002/JLB.3MA0322-279RRR Abstract The mitochondrial membrane potential (ΔΨm ) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of ΔΨm is implicated in several inflammatory-related pathologies, such [...]

Auhtors: Medini H, Zirmman A, Mishmar D PMID: 34812416 PMCID: PMC8599136 DOI: 10.1016/j.isci.2021.103471 Abstract Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections. Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available bulk RNA-seq datasets from COVID-19 patients and corresponding healthy controls (three blood datasets, N = [...]

Auhtors: Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, Chaves L PMID: 34599743 PMCID: PMC8487226 DOI: 10.1007/s11481-021-10015-6 Abstract Emerging clinical data from the current COVID-19 pandemic suggests that ~ 40% of COVID-19 patients develop neurological symptoms attributed to viral encephalitis while in COVID long haulers chronic neuro-inflammation and neuronal damage result in a [...]

Authors: Wood E, Hall KH, Tate W PMID: 33251031 PMCID: PMC7680046 DOI: 10.1016/j.cdtm.2020.11.002 Abstract A significant number of SARS-CoV-2 (COVID-19) pandemic patients have developed chronic symptoms lasting weeks or months which are very similar to those described for myalgic encephalomyelitis/chronic fatigue syndrome. This study reviews the current literature and understanding of the role that mitochondria, [...]

Authors: Tezgin D, Giardina C, Perdrizet GA, Hightower LE PMID: 32253741 PMCID: PMC7332662 doi: 10.1007/s12192-020-01100-5 Abstract We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of [...]

Auhtors: Chinopoulos C, Seyfried TN PMID: 30909720 PMCID: PMC6311572 DOI: 10.1177/1759091418818261 Abstract Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers. Ultrastructural and biochemical evidence shows that GBM cells exhibit mitochondrial abnormalities incompatible with energy production through oxidative phosphorylation (OxPhos). Under such conditions, the mitochondrial F0-F1 ATP synthase operates [...]

Auhtors: Galluzzi L, Morselli E, Kepp O, Vitale I, Rigoni A, Vacchelli E, et al. PMID: 19698742 DOI: 10.1016/j.mam.2009.08.002 Abstract Mitochondria are required for cellular survival, yet can also orchestrate cell death. The peculiar biochemical properties of these organelles, which are intimately linked to their compartmentalized ultrastructure, provide an optimal microenvironment for multiple biosynthetic and [...]

Auhtors: Kiebish MA, Han X, Cheng H, Chuang JH, Seyfried TN PMID: 18703489 PMCID: PMC2582368 DOI: 10.1194/jlr.M800319-JLR200 Abstract Otto Warburg first proposed that cancer originated from irreversible injury to mitochondrial respiration, but the structural basis for this injury has remained elusive. Cardiolipin (CL) is a complex phospholipid found almost exclusively in the inner mitochondrial membrane [...]

Auhtors: Clippinger AJ, Bouchard MJ PMID: 18448529 PMCID: PMC2446973 DOI: 10.1128/JVI.00154-08 Abstract Over 350 million people are chronically infected with hepatitis B virus (HBV), and a significant number of chronically infected individuals develop primary liver cancer. HBV encodes seven viral proteins, including the nonstructural X (HBx) protein. The results of studies with immortalized or transformed [...]

Auhtors: Singh KK, Kulawiec M, Still I, Desouki MM, Geradts J, Matsui SI PMID: 15979824 DOI: 10.1016/j.gene.2005.03.027 Abstract Mitochondrial dysfunction is a hallmark of cancer cells. Consistent with this phenotype mutations in mitochondrial genome have been reported in all cancers examined to date. However, it is not clear whether mitochondrial genomic status in human cells [...]