Auhtors: Xu R, Ji Z, Xu C, Zhu J PMID: 30431566 PMCID: PMC6257684 DOI: 10.1097/MD.0000000000012912 Abstract Background: Autophagy is a mechanism which relies on lysosomes for clearance and recycling of abnormal proteins or organelles. Many studies have demonstrated that the deregulation of autophagy is associated with the development of various diseases including cancer. The use [...]

Authors: Plantone D, Koudriavtseva T PMID: 29737455 DOI: 10.1007/s40261-018-0656-y Abstract The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), [...]

Auhtors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC, Fuchs CS PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Authors: Wolpin BM, Rubinson DA, Wang X, Chan JA, Cleary JM, Enzinger PC et al. PMID: 24821822 PMCID: PMC4041680 DOI: 10.1634/theoncologist.2014-0086 Abstract Background: Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition reduces pancreatic cancer growth in model systems. We evaluated hydoxychloroquine (HCQ), an inhibitor of autophagy, in patients [...]

Authors: Ruiz-Irastorza G, Khamashta MA PMID: 18413405 DOI: 10.1177/0961203307086643 Abstract No abstract available Keywords: Hydroxychloroquine, lupus Source: https://journals.sagepub.com/doi/pdf/10.1177/0961203307086643 Archive: https://archive.is/caIhQ