Auhtors: Liu Z, Peng Q, Li Y, Gao Y PMID: 30103844 PMCID: PMC6177506 DOI: 10.5483/BMBRep.2018.51.9.114 Abstract Cisplatin is one of the most effective chemotherapeutic drugs used in the treatment of HCC, but many patients will ultimately relapse with cisplatin-resistant disease. Used in combination with cisplatin, resveratrol has synergistic effect of increasing chemosensitivity of cisplatin in [...]

Auhtors: Chen Q, Kirk K, Shurubor YI, Zhao D, Arreguin AJ, Shahi I, et al. PMID: 29657030 PMCID: PMC5932217 DOI: 10.1016/j.cmet.2018.03.002 Abstract Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated [...]