Auhtors: Rawat SG, Tiwari RK, Jaiswara PK, Gupta VK, Sonker P, Vishvakarma NK, et al. PMID: 35725975 DOI: 10.1007/s10495-022-01741-0 Abstract Cyclic nucleotide phosphodiesterase 5 (PDE5) has been recently identified to play a crucial role in the progression of many cancers. PDE5 promotes tumorigenesis by dysregulating various cellular processes such as proliferation, apoptosis, angiogenesis, and invasion [...]

Authors: Reiter RJ, Sharma R, Ma Q, Liu C, Manucha W, Abreu-Gonzalez P DOI: https://doi.org/10.32794/mr11250068 Abstract COVID-19 has infected hundreds of thousands and killed tens of thousands of people worldwide and it continues to ravage societies as well as fiscal and economic stability of several countries. Currently, several drugs that were designed for other [...]

Auhtors: Santos HO, de Moraes WM, da Silva GA, restes J, Schoenfeld BJ PMID: 31221273 DOI: 10.1016/j.clnesp.2019.05.008 Abstract Vinegar intake is considered a food item that improves blood glucose in humans. This review aimed to discuss studies that investigated the impact of vinegar intake on the glycemic profile in humans and the putative mechanistic cellular [...]

Auhtors: León D, Uribe E, Zambrano A, Salas M PMID: 28272357 PMCID: PMC6155386 DOI: 10.3390/molecules22030398 Abstract Resveratrol-a polyphenol of natural origin-has been the object of massive research in the past decade because of its potential use in cancer therapy. However, resveratrol has shown an extensive range of cellular targets and effects, which hinders the use [...]

Auhtors: Antoni R, Johnston KL, Collins AL, Robertson MD. PMID: 28091348 DOI: 10.1017/S0029665116002986 Abstract Two intermittent fasting variants, intermittent energy restriction (IER) and time-restricted feeding (TRF), have received considerable interest as strategies for weight-management and/or improving metabolic health. With these strategies, the pattern of energy restriction and/or timing of food intake are altered so that [...]

Auhtors: Petsiou EI, Mitrou PI, Raptis SA, Dimitriadis GD PMID: 25168916 DOI: 10.1111/nure.12125 Abstract The aim of this review is to summarize the effects of vinegar on glucose and lipid metabolism. Several studies have demonstrated that vinegar can help reduce hyperglycemia, hyperinsulinemia, hyperlipidemia, and obesity. Other studies, however, have shown no beneficial effect on metabolism. [...]

Auhtors: Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, Deberardinis RJ PMID: 19826036 PMCID: PMC2764330 DOI: 10.1158/0008-5472.CAN-09-2266 Abstract Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor [...]