Auhtors: Mukherjee P, Augur ZM, Li M, Hill C, Greenwood B, Domin MA, et al. Abstract Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective therapy for decades. Although glucose and glutamine are the major fuels that drive GBM growth and invasion, few studies have targeted these fuels for therapeutic management. [...]

Auhtors: Jin F, Xie T, Huang X, Zhao X PMID: 31070539 PMCID: PMC6319470 DOI: 10.1080/13880209.2018.1548627 Abstract Context: Berberine is used in traditional Chinese medicine for thousands of years with recent reports of its anticancer activity. Objective: To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway. Materials and methods: [...]

Auhtors: Oizel K, Chauvin C, Oliver L, Gratas C, Geraldo F, Jarry U, et al. PMID: 28720668 DOI: 10.1158/1078-0432.CCR-16-3102 Abstract Purpose: Glioblastoma (GBM) is the most common and malignant form of primary human brain tumor in adults, with an average survival at diagnosis of 18 months. Metabolism is a new attractive therapeutic target in cancer; [...]

Auhtors: Liu Y, Fang S, Sun Q, Liu B PMID: 27771251 DOI: 10.1016/j.bbrc.2016.10.064 Abstract Glioblastoma is one of the most vascular brain tumour and highly resistant to current therapy. Targeting both glioblastoma cells and angiogenesis may present an effective therapeutic strategy for glioblastoma. In our work, we show that an anthelmintic drug, ivermectin, is active [...]

Auhtors: Yang C, Sudderth J, Dang T, Bachoo RG, McDonald JG, Deberardinis RJ PMID: 19826036 PMCID: PMC2764330 DOI: 10.1158/0008-5472.CAN-09-2266 Abstract Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamine addiction"), suggesting that treatments targeting glutamine metabolism might selectively kill c-Myc-transformed tumor [...]