Authors:Michelen M, Manoharan L, Elkheir N, Cheng V, Dagens D, Hastie C. . PMID: PMC8478580 DOI: 10.1136/bmjgh-2021-005427 Abstract Background: While it is now apparent clinical sequelae (long COVID) may persist after acute COVID-19, their nature, frequency and aetiology are poorly characterised. This study aims to regularly synthesise evidence on long COVID characteristics, to help inform [...]

Authors: Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Liu J PMID: 34478478 PMCID: PMC8415618 DOI: 10.1371/journal.pone.0257016 Abstract Background: Activation of the immune system is implicated in the Post-Acute Sequelae after SARS-CoV-2 infection (PASC) but the mechanisms remain unknown. Angiotensin-converting enzyme 2 (ACE2) cleaves angiotensin II (Ang II) resulting in decreased activation of [...]

Authors: Marconi VC, Ramanan AV, de Bono S, Kartman CE, Krishnan V PMID: 34480861 PMCID: PMC8409066 DOI: 10.1016/S2213-2600(21)00331-3 Abstract Background: Baricitinib is an oral selective Janus kinase 1/2 inhibitor with known anti-inflammatory properties. This study evaluates the efficacy and safety of baricitinib in combination with standard of care for the treatment of hospitalised adults with [...]

Authors: Dacasin AB, Diagono DM, So PK, Bautista VR, Bucu ML, Bueno PR DOI: 10.22271/phyto.2021.v10.i6a.14254 Abstract This review summarizes the background of Cocos nucifera, the benefits of the isolated virgin coconut oil (VCO), such as its potential as an adjunctive treatment for COVID-19, and its pharmacological effects, including antiviral and anti-inflammatory properties that could be [...]

Authors: Oliaei S, Mehrtak M, Karimi A, Noori T, Shojaei A, Dadras O PMID: 34412709 PMCID: PMC8374420 DOI: 10.1186/s40001-021-00570-2 Abstract Background: Oxygenation serves as a cornerstone in the treatment of COVID-19, and several methods have been extensively studied so far. Herein, we aimed to systematically review the studies discussing hyperbaric oxygen therapy (HBOT) to examine [...]

Authors: Kabinger F, Stiller C, Schmitzova J, Kokic G PMID: 34381216 PMCID: PMC8437801 DOI: 10.1038/s41594-021-00651-0 Abstract Molnupiravir is an orally available antiviral drug candidate currently in phase III trials for the treatment of patients with COVID-19. Molnupiravir increases the frequency of viral RNA mutations and impairs SARS-CoV-2 replication in animal models and in humans. Here, [...]

Authors: Yu LM, Bafadhel M, Doeward J, Hayward G PMID: 34388395 PMCID: PMC8354567 DOI: 10.1016/S0140-6736(21)01744-X Abstract Background: A previous efficacy trial found benefit from inhaled budesonide for COVID-19 in patients not admitted to hospital, but effectiveness in high-risk individuals is unknown. We aimed to establish whether inhaled budesonide reduces time to recovery and COVID-19-related hospital [...]

Authors: Patrick R Lawler, Ewan C Goligher, Jeffrey S Berger, Matthew D Neal, Bryan J McVerry, Jose C Nicolau, et al. PMID: 34351721 PMCID: PMC8362594 DOI: 10.1056/NEJMoa2105911 Abstract Background: Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve [...]

Authors: McCoy J, Goren A, Cadegiani FA, Vano-Galvan S, Kovacevic M, Situm M et al. PMID: 34350193 PMCID: PMC8326462 DOI: 10.3389/fmed.2021.668698 Abstract Antiandrogens have demonstrated a protective effect for COVOD-19 patients in observational and interventional studies. The goal of this study was to determine if proxalutamide, an androgen receptor antagonist, could [...]

Authors: Perrella F, Coppola F, Petrone A, Platells C, Montesarchio D, Ravagnan G PMID: 34356672 PMCID: PMC8301781 DOI: 10.3390/biom11071048 Abstract In the search for new therapeutic strategies to contrast SARS-CoV-2, we here studied the interaction of polydatin (PD) and resveratrol (RESV)-two natural stilbene polyphenols with manifold, well known biological activities-with Spike, the viral protein essential [...]