This study aimed to determine the effect of melatonin on thrombosis, sepsis, and mortality rate in adult patients with severe coronavirus infection (COVID-19).

Authors: Reddy MP, Subramaniam A, Afroz A, Billah B, Lim ZJ, Wong SN PMID: 33927120 PMCID: PMC8439644 DOI: 10.1097/CCM.0000000000005086 Abstract Objectives: Several studies have reported prone positioning of nonintubated patients with coronavirus diseases 2019-related hypoxemic respiratory failure. This systematic review and meta-analysis evaluated the impact of prone positioning on oxygenation and clinical outcomes. Design and [...]

Authors: Kakavas S, Karayiannis D, Mastora Z PMID: 34684460 PMCID: PMC8537261 DOI: 10.3390/nu13103458 Abstract There is an ongoing need for new therapeutic modalities against SARS-CoV-2 infection. Mast cell histamine has been implicated in the pathophysiology of COVID-19 as a regulator of proinflammatory, fibrotic, and thrombogenic processes. Consequently, mast cell histamine and its receptors represent promising [...]

Authors: Barbaro RP, MacLaren G, Boonstra PS, Iwashyna TJ, Slutsky AS PMID: 34599878 PMCID: PMC8480964 DOI: 10.1016/S0140-6736(21)01960-7 Abstract Background: Over the course of the COVID-19 pandemic, the care of patients with COVID-19 has changed and the use of extracorporeal membrane oxygenation (ECMO) has increased. We aimed to examine patient selection, treatments, outcomes, and ECMO centre [...]

Authors: Nogues X, Overjero D, Pineda-Moncus M, Bouillon R PMID: 34097036 PMCID: PMC8344647 DOI: 10.1210/clinem/dgab405 Abstract Context: COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. Objective: This work aims to elucidate the effect [...]

Authors: Marik P, Iglesias J, Varon J, Kory P PMID: 34569339 PMCID: PMC8477699 DOI: 10.1177/20587384211048026 Abstract COVID-19 is a highly heterogeneous and complex medical disorder; indeed, severe COVID-19 is probably amongst the most complex of medical conditions known to medical science. While enormous strides have been made in understanding the molecular pathways involved in patients [...]

Authors: Zuo T, Wu X, Wen W, Lan P PMID: 34560321 PMCID: PMC8478109 DOI: 10.1016/j.gpb.2021.09.004 Abstract Since the outset of the coronavirus disease 2019 (COVID-19) pandemic, the gut microbiome in COVID-19 has garnered substantial interest, given its significant roles in human health and pathophysiology. Accumulating evidence is unveiling that the gut microbiome is broadly altered [...]

Authors: Ader F, Hites M, Poissy J, Belhadi D, Diallo A, Staub T PMID: 34534511 PMCID: PMC8439621 DOI: 10.1016/S1473-3099(21)00485-0 Abstract Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital [...]

Authors: Draghici S, Nguyen TM, Sonna LA, Ziraldo C, Vanciu R, Fadel R et al. PMID: 33693506 PMCID: PMC7989618 DOI: 10.1093/bioinformatics/btab163 Abstract Motivation: COVID-19 has several distinct clinical phases: a viral replication phase, an inflammatory phase and in some patients, a hyper-inflammatory phase. High mortality is associated with patients developing cytokine storm syndrome. Treatment of [...]

Authors: Hurmach V, Platonov MO, Prylutska SV, Scharff P, Ritter U PMID: 34493768 PMCID: PMC8423725 DOI: 10.1038/s41598-021-97268-6 Abstract Based on WHO reports the new SARS-CoV-2 coronavirus is currently widespread all over the world. So far > 162 million cases have been confirmed, including > 3 million deaths. Because of the pandemic still spreading across the [...]